| WB | DB: 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mucin-1, MUC-1, Breast carcinoma-associated antigen DF3, Cancer antigen 15-3, CA 15-3, Carcinoma-associated mucin, Episialin, H23AG, Krebs von den Lungen-6, KL-6, PEMT, Peanut-reactive urinary mucin, PUM, Polymorphic epithelial mucin, PEM, Tumor-associated epithelial membrane antigen, EMA, Tumor-associated mucin, CD227, Mucin-1 subunit alpha, MUC1-NT, MUC1-alpha, Mucin-1 subunit beta, MUC1-beta, MUC1-CT, MUC1, PUM |
| Entrez GeneID | 4582 |
| WB Predicted band size | 122.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MUC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T1224 of human MUC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 **Phospho-MUC1 (T1224)** 抗体的参考文献示例(文献为虚构，仅供格式参考)：
1. **《Phosphorylation of MUC1 on Threonine 1224 Promotes Oncogenic Signaling in Breast Cancer》**
- **作者**: Li Y, Wang X, et al.
- **摘要**: 研究揭示了 MUC1 在 T1224 位点的磷酸化通过激活 PI3K/AKT 通路促进乳腺癌细胞增殖和迁移，文中使用 Phospho-MUC1 (T1224) 抗体验证了磷酸化水平与临床预后的相关性。
2. **《Development of a Phospho-Specific Antibody Targeting MUC1-T1224 for Monitoring Tumor Progression》**
- **作者**: Smith JL, Brown KR, et al.
- **摘要**: 报道了一种针对 MUC1-T1224 磷酸化表位的单克隆抗体的开发，通过免疫组化及 Western blot 验证其在结直肠癌组织中的特异性，并证明其作为生物标志物的潜力。
3. **《MUC1 Phosphorylation at T1224 Modulates Immune Evasion in Pancreatic Ductal Adenocarcinoma》**
- **作者**: Gupta R, Patel S, et al.
- **摘要**: 探讨 T1224 磷酸化 MUC1 通过抑制 T 细胞活性促进胰腺癌免疫逃逸，研究利用 Phospho-MUC1 (T1224) 抗体揭示其与 PD-L1 表达的协同作用。
4. **《A Novel Role of MUC1-T1224 Phosphorylation in Chemoresistance via Stabilizing β-Catenin》**
- **作者**: Zhang Q, Liu T, et al.
- **摘要**: 发现 MUC1-T1224 磷酸化通过增强 β-catenin 的稳定性诱导卵巢癌化疗耐药，研究通过该抗体证实磷酸化水平与患者化疗反应负相关。
(注：以上文献为示例，实际文献需通过 PubMed 或 Web of Science 等平台检索确认。)
Phospho-MUC1(T1224) antibody is a specialized tool used to detect the phosphorylated form of MUC1 (Mucin 1) at threonine residue 1224. MUC1 is a transmembrane glycoprotein overexpressed in many epithelial cancers, including breast, pancreatic, and ovarian cancers. Its cytoplasmic tail contains multiple phosphorylation sites that regulate interactions with signaling molecules, influencing cell proliferation, survival, and metastasis. Phosphorylation at T1224. located within the C-terminal domain of MUC1. is linked to activation of signaling pathways such as PI3K/AKT and ERK, often mediated by receptor tyrosine kinases or stress-activated kinases. This modification enhances MUC1's ability to bind β-catenin, disrupting cell-cell adhesion and promoting oncogenic transcriptional activity.
The Phospho-MUC1(T1224) antibody is widely used in cancer research to study MUC1's role in tumor progression, drug resistance, and metastasis. It helps identify phosphorylated MUC1 in cell lysates (via Western blot) or tissue samples (via immunohistochemistry), offering insights into pathway activation status. Studies using this antibody have revealed correlations between MUC1 phosphorylation and poor prognosis in cancer patients, highlighting its potential as a therapeutic target or biomarker. Researchers also employ it to evaluate the efficacy of kinase inhibitors or targeted therapies aimed at disrupting MUC1-associated signaling networks. Proper validation with phosphorylation-specific controls is essential to ensure antibody specificity in experimental settings.
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