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Rabbit Polyclonal IMP2L Antibody

  • 中文名: IMP2L抗体
  • 别    名: Mitochondrial inner membrane protease subunit 2, 3421-, IMP2-like protein, IMMP2L
货号: IPDX30599
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMitochondrial inner membrane protease subunit 2, 3421-, IMP2-like protein, IMMP2L
Entrez GeneID83943
WB Predicted band size19.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis IMP2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-109 amino acids from the Central region of human IMP2L.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于IMP2L抗体的模拟参考文献示例(实际文献需通过学术数据库检索确认):

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1. **标题**: *IMP2L regulates neural progenitor proliferation via RNA stabilization*

**作者**: Smith A, et al.

**摘要**: 本研究利用IMP2L特异性抗体探究了其在胚胎神经发育中的作用。发现IMP2L通过结合特定mRNA(如Notch通路相关基因)调控其稳定性,影响神经前体细胞增殖,缺失导致小鼠皮层发育异常。

2. **标题**: *Development of a monoclonal antibody against human IMP2L for cancer diagnostics*

**作者**: Chen L, et al.

**摘要**: 文章报道了一种高特异性抗人IMP2L单克隆抗体的制备及验证。该抗体可通过免疫组化检测多种肿瘤组织(如胶质瘤、结肠癌)中IMP2L的异常高表达,提示其作为潜在生物标志物的价值。

3. **标题**: *IMP2L interacts with RNA-binding complexes in stress granules*

**作者**: González-Rico D, et al.

**摘要**: 通过免疫共沉淀(使用IMP2L抗体)和质谱分析,揭示了IMP2L在细胞应激条件下参与应激颗粒形成的分子机制,其与TIA-1等蛋白的相互作用可能影响细胞应激应答和凋亡通路。

4. **标题**: *Chromosomal deletion of IMP2L in 18q21 syndrome: Functional validation using CRISPR and antibody-based assays*

**作者**: Tanaka K, et al.

**摘要**: 研究结合CRISPR基因编辑和IMP2L抗体检测,证实18q21染色体缺失综合征中IMP2L的杂合缺失导致细胞迁移能力下降,可能与患者的神经发育表型相关。

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**注**:以上为模拟文献,实际研究中请通过PubMed、Google Scholar等平台检索关键词(如“IMP2L antibody”、“IGF2BP2-like”)获取最新进展。部分研究可能聚焦于IMP2L的同源蛋白(如IGF2BP家族),需注意区分。

背景信息

The IMP2L (IGF2BP2-like) antibody targets the IMP2L protein, a member of the insulin-like growth factor 2 mRNA-binding protein (IGF2BP/IMP) family. IMP2L, encoded by the *IGF2BP2* gene, shares structural homology with IMP2 (IGF2BP2) and IMP1 (IGF2BP1), featuring RNA-binding motifs critical for post-transcriptional gene regulation. It binds to mRNA targets, influencing stability, localization, and translation, thereby modulating cellular processes like proliferation, differentiation, and metabolism. IMP2L is implicated in neurodevelopment and has been linked to autism spectrum disorders (ASD) and intellectual disabilities due to its role in neuronal RNA metabolism. Chromosomal deletions or mutations in the 15q21.3 region (where *IGF2BP2* resides) are associated with these conditions. The IMP2L antibody is widely used in research to detect protein expression, study its interaction with RNA targets, and explore its pathological mechanisms in developmental disorders and cancers. As a tool for immunohistochemistry, Western blotting, or immunofluorescence, it aids in elucidating IMP2L's tissue-specific functions and potential therapeutic targets. Its specificity and validation across experimental models make it essential for molecular and clinical studies.

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