| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Up-regulator of cell proliferation, HBV X protein up-regulated gene 4 protein, HBxAg up-regulated gene 4 protein, URGCP, KIAA1507 {ECO:0000312|EMBL:BAA960311}, URG4 |
| Entrez GeneID | 55665 |
| WB Predicted band size | 105.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This URG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 466-495 amino acids from the Central region of human URG4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3-4条关于URG4抗体的参考文献示例(内容为虚构模拟，仅供参考，实际文献请通过学术数据库验证)：
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1. **文献名称**：*URG4 promotes hepatocellular carcinoma progression via PI3K/AKT pathway activation*
**作者**：Zhang Y, Li J, et al.
**摘要**：该研究利用URG4抗体检测肝癌组织中URG4蛋白的表达水平，发现其高表达与PI3K/AKT信号通路的激活相关，提示URG4可能通过调控该通路促进肿瘤侵袭转移。
2. **文献名称**：*URG4 as a diagnostic biomarker in gastric cancer: An immunohistochemical study*
**作者**：Wang L, Chen X, et al.
**摘要**：通过URG4抗体进行免疫组化分析，发现胃癌组织中URG4蛋白表达显著高于正常组织，且与患者预后不良相关，提示其可作为潜在的诊断标志物。
3. **文献名称**：*Silencing URG4 inhibits colorectal cancer cell proliferation via Wnt/β-catenin signaling*
**作者**：Liu H, Zhou M, et al.
**摘要**：研究利用URG4抗体及siRNA技术，证实抑制URG4表达可通过阻断Wnt/β-catenin通路抑制结直肠癌细胞增殖，为靶向治疗提供依据。
4. **文献名称**：*URG4 antibody-based ELISA assay for early detection of liver fibrosis*
**作者**：Kim S, Tanaka R, et al.
**摘要**：开发了一种基于URG4抗体的ELISA检测方法，用于定量血清中URG4水平，结果显示其在肝纤维化早期诊断中具有较高敏感性和特异性。
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**注意**：以上内容为示例，实际文献需通过PubMed、Google Scholar等平台检索关键词(如"URG4 antibody"、"URG4 cancer")。真实文献可能涉及URG4在肿瘤发生、转移或耐药性中的机制研究。
URG4 antibody is a research tool designed to detect the Upregulated in Renal Cell Carcinoma Gene 4 (URG4) protein, also known as C13orf25 or UPF0364. Initially identified for its overexpression in hepatocellular carcinoma (HCC), URG4 is implicated in tumorigenesis across multiple cancers, including gastric, cervical, and colorectal cancers. The protein promotes cell proliferation, inhibits apoptosis, and enhances tumor invasiveness, partly by modulating pathways like Wnt/β-catenin and PI3K/Akt.
URG4 antibodies, typically monoclonal or polyclonal, are utilized in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study URG4 expression patterns in tissues or cell lines. Elevated URG4 levels correlate with advanced tumor stages, metastasis, and poor prognosis, suggesting its potential as a diagnostic or prognostic biomarker. Research also explores its role in therapeutic targeting, as silencing URG4 reduces tumor growth in preclinical models.
Despite progress, URG4's precise molecular mechanisms remain partially understood. Antibody specificity and validation are critical, given homology with other family members. Ongoing studies aim to clarify URG4's interactions and therapeutic relevance, solidifying its antibody as a key reagent in cancer biology.
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