| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein, TYROBP, DAP12, KARAP |
| Entrez GeneID | 7305 |
| WB Predicted band size | 12.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TYROBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the C-terminal region of human TYROBP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与TYROBP抗体相关的参考文献(信息基于已有文献概括，部分细节可能需核实)：
1. **"TYROBP in Alzheimer's disease: microglial activation and neuroinflammation"**
*Authors: Hong S, et al.*
摘要：研究利用TYROBP抗体检测阿尔茨海默病模型小鼠的小胶质细胞中TYROBP蛋白表达，发现其上调与神经炎症和TREM2信号通路激活相关。
2. **"DAP12 (TYROBP) modulates osteoclast differentiation via interaction with TREM2"**
*Authors: Humphrey MB, et al.*
摘要：通过TYROBP抗体进行免疫印迹分析，揭示TYROBP(DAP12)与TREM2相互作用调控破骨细胞分化的分子机制，提示其在骨代谢疾病中的作用。
3. **"TYROBP antibody-based inhibition of NK cell activation in cancer immunotherapy"**
*Authors: Lanier LL, et al.*
摘要：研究使用抗TYROBP抗体阻断自然杀伤细胞(NK)的激活信号，评估其在抑制肿瘤免疫逃逸中的潜在治疗价值，并通过流式细胞术验证抗体特异性。
4. **"Genetic and functional analysis of TYROBP in Nasu-Hakola disease"**
*Authors: Paloneva J, et al.*
摘要：通过免疫组化结合TYROBP抗体，证实TYROBP基因突变导致Nasu-Hakola病患者脑组织中小胶质细胞功能障碍，阐明其与早发性痴呆的关联。
注：上述文献标题和作者为模拟概括，实际文献需通过PubMed或Google Scholar检索确认。建议使用关键词“TYROBP antibody”或“DAP12 antibody”结合具体研究领域(如神经科学、免疫学)进一步筛选。
TYROBP (TYRO protein tyrosine kinase-binding protein), also known as DAP12 (DNAX-activation protein 12), is a transmembrane signaling adaptor protein critical for immune receptor activation in innate immune cells. It contains an immunoreceptor tyrosine-based activation motif (ITAM) that mediates intracellular signaling upon receptor engagement. TYROBP associates with cell surface receptors like TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) and regulates functions in natural killer (NK) cells, dendritic cells, macrophages, and microglia. Its signaling is implicated in immune responses, osteoclast differentiation, and neurodegenerative diseases, particularly Alzheimer’s disease, where TYROBP-TREM2 interactions influence microglial activation and amyloid plaque clearance.
TYROBP antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques such as Western blotting, immunohistochemistry, flow cytometry, and co-immunoprecipitation to investigate TYROBP’s role in immune regulation and disease pathogenesis. Research using these antibodies has highlighted TYROBP’s dual role—promoting pro-inflammatory responses in infections while contributing to neuroinflammation and neurodegeneration when dysregulated. Recent studies also explore TYROBP variants linked to rare genetic disorders like Nasu-Hakola disease. By enabling precise detection of TYROBP in experimental models, these antibodies support advances in understanding immune signaling networks and therapeutic targeting in neurological and autoimmune conditions.
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