| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein PAT1 homolog 1, PAT1-like protein 1, Protein PAT1 homolog b, Pat1b, hPat1b, PATL1 |
| Entrez GeneID | 219988 |
| WB Predicted band size | 86.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PATL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-518 amino acids from the C-terminal region of human PATL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PATL1抗体的3篇参考文献示例(文献信息为模拟示例，具体需根据实际数据库检索补充)：
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1. **文献名称**：*PATL1 is a key regulator of mRNA metabolism and cell proliferation in cancer*
**作者**：Smith A, et al.
**摘要**：本研究报道了PATL1蛋白在肿瘤细胞mRNA代谢中的作用，开发了兔源多克隆PATL1抗体，并通过免疫印迹和免疫荧光验证其特异性，证明PATL1表达下调抑制癌细胞增殖。
2. **文献名称**：*Development and validation of a monoclonal antibody for detecting PATL1 in human tissues*
**作者**：Chen L, et al.
**摘要**：文章描述了一种新型小鼠单克隆PATL1抗体的制备，通过ELISA和免疫组化验证其灵敏度，应用于卵巢癌组织样本检测，显示PATL1表达与患者预后相关。
3. **文献名称**：*PATL1 interacts with DDX6 to modulate stress granule formation*
**作者**：Wang Y, et al.
**摘要**：研究利用商业PATL1抗体(货号AB123.Sigma公司)进行共免疫沉淀实验，发现PATL1与RNA解旋酶DDX6相互作用，参与细胞应激颗粒的调控机制。
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**注**：以上文献为示例模板，实际引用需通过PubMed、Web of Science等平台检索关键词“PATL1 antibody”或“PATL1 protein”获取真实文献。若研究领域较新，建议扩展检索词或关注相关蛋白功能研究中间接提及抗体的文献。
The PATL1 antibody is designed to target the PATL1 (Protein Associated with Topoisomerase II homolog 1) protein, a conserved RNA-binding protein implicated in diverse cellular processes. PATL1 is primarily known for its role in mRNA metabolism, including translational regulation, RNA localization, and decay. It interacts with components of the cytoplasmic RNA granule machinery, such as DDX6 and LSM14. suggesting involvement in post-transcriptional gene silencing and stress granule dynamics. Studies highlight its importance in oogenesis, embryogenesis, and germ cell development, where it contributes to mRNA storage and stability during early developmental stages. Dysregulation of PATL1 has been linked to infertility and developmental disorders.
The PATL1 antibody serves as a critical tool for detecting PATL1 expression and localization via techniques like Western blotting, immunofluorescence, and immunoprecipitation. It aids in elucidating PATL1's molecular interactions and functional mechanisms in cellular models, such as human cell lines or model organisms. Validated in species like humans and mice, this antibody supports research in reproductive biology, neurodevelopment, and RNA biology. Its specificity and reliability make it essential for exploring PATL1's regulatory roles in health and disease, including potential connections to cancer or neurodegenerative conditions. Ongoing studies continue to expand its applications in both basic and translational research.
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