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Rabbit Polyclonal ATP5A1 Antibody

  • 中文名： ATP5A1抗体
  • 别    名： ATP synthase subunit alpha, mitochondrial, ATP5A1, ATP5A, ATP5AL2, ATPM
货号: IPDX30539
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesATP synthase subunit alpha, mitochondrial, ATP5A1, ATP5A, ATP5AL2, ATPM
Entrez GeneID498
WB Predicted band size59.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ATP5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 477-503 amino acids from the C-terminal region of human ATP5A1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于ATP5A1抗体的3篇参考文献示例(注：以下为模拟内容，实际文献需通过学术数据库检索)：

1. **文献名称**：*ATP5A1 modulates mitochondrial dysfunction in Alzheimer's disease*

**作者**：Smith J, et al.

**摘要**：该研究利用ATP5A1抗体进行Western blot和免疫组化分析，发现阿尔茨海默病患者脑组织中ATP5A1表达显著降低，提示线粒体ATP合成障碍可能与疾病进展相关。

2. **文献名称**：*Proteomic profiling of ATP synthase subunits in hepatocellular carcinoma*

**作者**：Li X, et al.

**摘要**：通过ATP5A1抗体结合质谱技术，作者发现肝癌细胞中线粒体ATP合酶复合体(包括ATP5A1)的异常组装，可能与肿瘤代谢重编程有关。

3. **文献名称**：*Validation of a novel ATP5A1 monoclonal antibody for cardiac tissue analysis*

**作者**：Garcia R, et al.

**摘要**：本研究报道了一种高特异性ATP5A1单克隆抗体的开发与验证，证实其在心肌缺血模型中线粒体蛋白质定位检测的可靠性，适用于病理状态下的能量代谢研究。

建议通过PubMed或Google Scholar以关键词“ATP5A1 antibody”、“ATP synthase alpha subunit antibody”检索最新文献，并优先选择近5年内发表的实验性论文。

背景信息

ATP5A1 antibody targets the alpha subunit of mitochondrial ATP synthase, a key component of Complex V in the oxidative phosphorylation (OXPHOS) pathway. ATP5A1 (ATP synthase F1 subunit alpha) is critical for catalyzing ATP production by coupling proton translocation across the mitochondrial inner membrane to adenosine triphosphate synthesis. As a highly conserved protein, ATP5A1 is ubiquitously expressed across tissues with high energy demands, such as brain, heart, and skeletal muscle. Antibodies against ATP5A1 are widely used to study mitochondrial function, cellular metabolism, and diseases linked to OXPHOS defects, including neurodegenerative disorders, cancer, and metabolic syndromes. In research, these antibodies enable detection of ATP5A1 via techniques like Western blot, immunohistochemistry, and immunofluorescence, aiding in the assessment of mitochondrial integrity and bioenergetic status. They also help investigate post-translational modifications or altered expression of ATP synthase in pathological conditions. Commercial ATP5A1 antibodies are typically raised in hosts like rabbits or mice, with validation including knockout cell line controls or siRNA knockdown to confirm specificity. Due to the existence of isoforms and homologous subunits, antibody validation is crucial to avoid cross-reactivity. Studies using ATP5A1 antibodies contribute to understanding metabolic reprogramming in cancer, aging-related mitochondrial dysfunction, and therapeutic targeting of energy metabolism pathways.

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