| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein LMBR1L, Limb region 1 protein homolog-like, Lipocalin-1-interacting membrane receptor, Lipocalin-interacting membrane receptor, LMBR1L, KIAA1174, LIMR |
| Entrez GeneID | 55716 |
| WB Predicted band size | 55.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This LMBR1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 462-489 amino acids from the C-terminal region of human LMBR1L. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LMBR1L抗体的3篇虚构参考文献(基于领域知识模拟，非真实文献)：
1. **文献名称**: *"LMBR1L regulates B-cell receptor signaling through interaction with phosphoinositides"*
**作者**: Smith J, et al. (2020)
**摘要**: 本研究利用特异性抗LMBR1L抗体(克隆号：AB-L1)通过Western blot和免疫共沉淀技术，揭示了LMBR1L蛋白在B细胞受体信号转导中的作用，发现其通过结合磷脂酰肌醇调控下游激酶活性。
2. **文献名称**: *"Development of a polyclonal antibody against LMBR1L and its application in cancer biomarker screening"*
**作者**: Zhang Y, et al. (2019)
**摘要**: 文章报道了一种兔源多克隆抗体的制备方法，该抗体针对人LMBR1L蛋白C端抗原表位，并通过免疫组化验证其在结直肠癌组织中的异常高表达，提示LMBR1L可能作为肿瘤预后标志物。
3. **文献名称**: *"LMBR1L modulates TLR4-mediated inflammatory responses in macrophages via antibody-blocking assays"*
**作者**: Lee S, Kim H. (2021)
**摘要**: 通过抗LMBR1L中和抗体阻断实验，研究发现LMBR1L与TLR4受体复合物存在物理互作，抑制其功能可降低巨噬细胞中IL-6和TNF-α的分泌，提示其在先天免疫中的调控作用。
注：以上为模拟文献，实际研究中请通过PubMed或Web of Science以“LMBR1L antibody”为关键词检索真实文献。
The LMBR1L (Limb Development Membrane Protein 1 Like) antibody is a tool used to study the LMBR1L protein, a transmembrane protein encoded by the *LMBR1L* gene. While the exact function of LMBR1L remains under investigation, it is implicated in developmental processes and cellular signaling pathways. Studies suggest its potential role in modulating the Hedgehog (Hh) signaling pathway, which is critical for embryonic development, tissue homeostasis, and cancer progression. LMBR1L shares structural homology with LMBR1. a protein linked to limb patterning defects in humans and animal models.
LMBR1L antibodies are primarily employed in research to detect protein expression, localization, and interaction partners via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate LMBR1L’s tissue-specific expression patterns and its potential involvement in diseases, including cancers and developmental disorders. Recent studies highlight LMBR1L’s possible regulatory effects on immune responses, as it is expressed in immune cells and may influence cytokine signaling.
Commercially available LMBR1L antibodies are typically produced in hosts like rabbits or mice, targeting specific epitopes within the protein. Validation data, including knockout controls, ensure specificity. Ongoing research aims to clarify LMBR1L’s mechanistic contributions to signaling pathways and its utility as a biomarker or therapeutic target. However, further functional studies are needed to fully define its biological and clinical significance.
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