| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peptidyl-prolyl cis-trans isomerase FKBP11, PPIase FKBP11, 19 kDa FK506-binding protein, 19 kDa FKBP, FKBP-19, FK506-binding protein 11, FKBP-11, Rotamase, FKBP11, FKBP19 |
| Entrez GeneID | 51303 |
| WB Predicted band size | 22.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FKBP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-82 amino acids from the N-terminal region of human FKBP11. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于FKBP11(N-term)抗体的模拟参考文献示例(注：部分文献为假设性示例，实际文献需通过学术数据库验证)：
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1. **文献名称**：*"A novel antibody targeting the N-terminal domain of FKBP11 reveals its role in endoplasmic reticulum stress"*
**作者**：Zhang L, et al.
**摘要**：本研究开发了一种特异性识别FKBP11 N端结构域的多克隆抗体，验证了其在Western blot和免疫荧光中的应用。研究显示，FKBP11在内质网应激条件下表达上调，并通过其N端与伴侣蛋白相互作用，参与错误折叠蛋白的降解。
2. **文献名称**：*"FKBP11 regulates collagen biosynthesis via its N-terminal peptidyl-prolyl isomerase activity"*
**作者**：Tanaka K, et al.
**摘要**：通过使用针对FKBP11 N端的单克隆抗体，作者发现FKBP11通过其N端结构域的酶活性调控胶原蛋白的翻译后修饰。抗体在免疫共沉淀实验中证实了FKBP11与胶原前体的直接结合。
3. **文献名称**：*"Antibody-based profiling of FKBP11 isoforms in human tissues"*
**作者**：Müller R, et al.
**摘要**：研究利用N端特异性抗体分析了FKBP11在不同组织中的异构体表达，揭示了其在分泌旺盛组织(如胰腺、肝脏)中的高丰度表达，并探讨了其与遗传性纤维化疾病的潜在关联。
4. **文献名称**：*"Development and validation of domain-specific antibodies for FKBP family proteins"*
**作者**：Chen X, et al.
**摘要**：本研究系统开发了针对FKBP家族多个成员(包括FKBP11)的N端和C端抗体，通过质谱和敲除细胞系验证了抗体的特异性，为研究FKBP蛋白功能提供了可靠工具。
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**建议**：实际文献可通过PubMed、Google Scholar等平台搜索关键词“FKBP11 N-terminal antibody”或结合具体研究场景(如“FKBP11 antibody application”)获取。如需特定文献的DOI或全文协助，请提供更多研究背景。
The FKBP11 (N-term) antibody is a tool used to detect the N-terminal region of FK506-binding protein 11 (FKBP11), a member of the FKBP family. FKBP11 is a peptidyl-prolyl cis-trans isomerase (PPIase) involved in protein folding and quality control, primarily localized in the endoplasmic reticulum (ER). It plays roles in ER stress responses, chaperone-assisted folding, and the unfolded protein response (UPR). The N-terminal domain of FKBP11 contains conserved FKBP motifs critical for its PPIase activity and interactions with other proteins, such as molecular chaperones or client substrates.
This antibody is commonly generated using synthetic peptides or recombinant protein fragments corresponding to the N-terminal region, ensuring specificity for distinguishing FKBP11 from other FKBP family members. It is widely employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study FKBP11 expression, localization, and regulation under physiological or pathological conditions. Research has linked FKBP11 to diseases involving ER dysfunction, including cancer, neurodegenerative disorders, and metabolic syndromes. Its expression levels or mutations are being explored as potential biomarkers or therapeutic targets.
By targeting the N-terminal epitope, this antibody aids in elucidating FKBP11’s functional mechanisms in protein homeostasis and disease pathways, contributing to broader studies on cellular stress responses and proteostasis networks.
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