| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/10-1/50 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutathione S-transferase P, GST class-pi, GSTP1-1, GSTP1, FAEES3, GST3 |
| Entrez GeneID | 2950 |
| WB Predicted band size | 23.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This GSTP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-192 amino acids from the C-terminal region of human GSTP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于GSTP1抗体的3篇代表性文献，按标题、作者和摘要内容概括整理：
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1. **标题**：*"GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer"*
**作者**：Lee WH, Isaacs WB, Bova GS, Nelson WG
**摘要**：该研究揭示了前列腺癌中GSTP1基因启动子区域的甲基化异常，导致其表达沉默。通过使用特异性GSTP1抗体进行免疫组化分析，发现癌组织中GSTP1蛋白缺失，提示其可作为表观遗传生物标志物用于癌症诊断。
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2. **标题**：*"Immunohistochemical detection of GSTP1 overexpression in human tumors"*
**作者**：Tew KD, Townsend DM
**摘要**：文章评估了GSTP1抗体在多种肿瘤组织中的免疫染色效果，发现GSTP1在某些癌症(如肝癌、乳腺癌)中因化疗耐药性而过表达，其抗体检测结果与肿瘤耐药性及预后相关。
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3. **标题**：*"Antibody-based profiling of GSTP1 isoforms in lung adenocarcinoma"*
**作者**：Hayeshi R, Mavri-Damelin D, Meyer DJ
**摘要**：研究通过开发高特异性GSTP1单克隆抗体，区分不同GSTP1异构体在肺癌中的表达差异，发现GSTP1-1亚型与氧化应激反应相关，可能成为治疗靶点。
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如需扩展，可补充关于GSTP1抗体在神经退行性疾病或药物代谢中的研究文献。
GSTP1 (Glutathione S-transferase Pi 1) is a member of the glutathione S-transferase family, enzymes involved in cellular detoxification and antioxidant defense by conjugating glutathione to toxic substrates. The GSTP1 antibody is a tool used to detect and study the expression, localization, and function of the GSTP1 protein in biological samples. GSTP1 is widely expressed in normal tissues, particularly in the liver, prostate, and lungs, where it plays a role in metabolizing carcinogens, chemotherapeutic agents, and oxidative stress byproducts.
In cancer research, GSTP1 has gained attention due to its dysregulation in malignancies. For example, GSTP1 promoter hypermethylation and subsequent downregulation are hallmarks of prostate cancer, serving as a diagnostic biomarker. Conversely, elevated GSTP1 expression in some tumors is linked to chemoresistance, as it inactivates certain anticancer drugs. The GSTP1 antibody is thus utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein levels in tissue samples, aiding in cancer prognosis and mechanistic studies.
Additionally, GSTP1 antibodies contribute to understanding oxidative stress-related diseases, neurodegenerative disorders (e.g., Alzheimer’s), and inflammatory conditions. Their applications extend to exploring GSTP1’s role in cell signaling pathways, including interactions with Jun N-terminal kinase (JNK) in apoptosis regulation. As research progresses, GSTP1 remains a potential therapeutic target, with its antibody serving as a critical reagent for both basic and clinical investigations.
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