| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitochondrial import receptor subunit TOM70, Mitochondrial precursor proteins import receptor, Translocase of outer membrane 70 kDa subunit, TOMM70A, KIAA0719, TOM70 |
| Entrez GeneID | 9868 |
| WB Predicted band size | 67.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TOMM70A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 579-608 amino acids from the C-terminal region of human TOMM70A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
+ +
以下是关于TOMM70A抗体的3篇模拟参考文献(注：以下内容为基于学术背景的合理示例，非真实存在的文献)：
---
1. **文献名称**: *TOMM70A Antibody Validation in Mitochondrial Protein Import Studies*
**作者**: Müller, J. et al.
**摘要**: 本研究验证了TOMM70A抗体在检测线粒体外膜转位酶复合体中的特异性，证实其在HeLa细胞线粒体裂解液中的免疫印迹效果，并揭示了TOMM70A与HSP90在蛋白质转运中的相互作用。
---
2. **文献名称**: *Autoantibodies Against TOMM70A in Autoimmune Hepatitis*
**作者**: Tanaka, S. et al.
**摘要**: 通过ELISA和免疫荧光技术，发现TOMM70A抗体在自身免疫性肝炎患者血清中显著升高，提示其可能作为新型生物标志物用于疾病诊断和机制研究。
---
3. **文献名称**: *Structural Insights into TOMM70A Recognition by Monoclonal Antibodies*
**作者**: Chen, L. et al.
**摘要**: 利用冷冻电镜技术解析了TOMM70A与其单克隆抗体的结合表位，揭示了抗体靶向的C端结构域在线粒体前体蛋白识别中的关键作用，为药物开发提供结构基础。
---
如需真实文献，建议通过PubMed或Google Scholar检索关键词“TOMM70A antibody”或“TOMM70A autoantibody”获取最新研究。
TOMM70A (Translocase of Outer Mitochondrial Membrane 70 Homolog A) is a critical component of the mitochondrial protein import machinery. Located in the outer mitochondrial membrane, it functions as part of the TOM (Translocase of the Outer Membrane) complex, which facilitates the recognition and translocation of nuclear-encoded precursor proteins into mitochondria. Specifically, TOMM70A acts as a receptor for precursor proteins carrying internal targeting signals, such as those destined for the inner mitochondrial membrane or matrix. It interacts with cytosolic chaperones like Hsp90. ensuring proper folding and delivery of substrate proteins.
Antibodies targeting TOMM70A are widely used in mitochondrial research to study protein import mechanisms, mitochondrial dynamics, and organelle integrity. They serve as essential tools in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect TOMM70A expression levels, localization, and interactions. Dysregulation of TOMM70A has been implicated in diseases linked to mitochondrial dysfunction, including neurodegenerative disorders (e.g., Parkinson’s disease), metabolic syndromes, and cancers. For instance, reduced TOMM70A levels may impair mitochondrial protein import, contributing to cellular stress and apoptosis.
Commercial TOMM70A antibodies are typically raised against specific epitopes, often validated for cross-reactivity in human, mouse, or rat models. Researchers rely on these antibodies to explore mitochondrial adaptations in energy-demanding conditions or to investigate pathological mechanisms in disease models. Recent studies also highlight its role in immune signaling, connecting mitochondrial protein import to inflammatory responses.
×
