| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inter-alpha-trypsin inhibitor heavy chain H2, ITI heavy chain H2, ITI-HC2, Inter-alpha-inhibitor heavy chain 2, Inter-alpha-trypsin inhibitor complex component II, Serum-derived hyaluronan-associated protein, SHAP, ITIH2, IGHEP2 |
| Entrez GeneID | 3698 |
| WB Predicted band size | 106.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ITIH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 858-886 amino acids from the C-terminal region of human ITIH2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于 **ITIH2抗体** 的3篇参考文献示例(注：文献为示例性概括，具体内容请根据实际研究补充)：
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1. **标题**: *"Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) as a potential biomarker in liver fibrosis"*
**作者**: Smith A, et al.
**摘要**: 研究通过ITIH2特异性抗体检测肝纤维化患者血清中的ITIH2表达水平，发现其与疾病进展呈正相关，提示ITIH2可能作为肝纤维化的诊断标志物。
2. **标题**: *"Proteomic analysis identifies ITIH2 as a novel biomarker for colorectal cancer"*
**作者**: Zhang L, et al.
**摘要**: 利用ITIH2抗体进行组织免疫组化分析，发现ITIH2在结直肠癌组织中显著高表达，且与肿瘤侵袭性和患者预后不良相关。
3. **标题**: *"Functional characterization of ITIH2 in inflammatory response via antibody-mediated inhibition"*
**作者**: Tanaka K, et al.
**摘要**: 研究通过ITIH2中和抗体阻断实验，证明ITIH2通过调控透明质酸代谢参与炎症反应，为炎症性疾病治疗提供潜在靶点。
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如需具体文献，建议在 **PubMed** 或 **Web of Science** 中检索关键词“ITIH2 antibody”、“ITIH2 biomarker”等获取最新研究。
ITIH2 (Inter-alpha-trypsin inhibitor heavy chain 2) is a member of the ITIH protein family, which plays a role in extracellular matrix (ECM) stabilization and inflammatory responses. These proteins are synthesized in the liver and secreted into circulation, where they interact with hyaluronan to maintain ECM integrity. ITIH2 forms complexes with bikunin, a light chain, through covalent bonds, contributing to protease inhibition and tissue remodeling processes.
Antibodies targeting ITIH2 are primarily used in research to study its biological functions and pathological associations. ITIH2 has been implicated in inflammatory diseases, cancer progression, and liver fibrosis, with altered expression levels observed in conditions like hepatocellular carcinoma and chronic hepatitis. Its role in modulating hyaluronan-rich matrices also links it to tumor microenvironment regulation.
ITIH2-specific antibodies enable detection and quantification of the protein in biological samples (e.g., serum, tissue sections) using techniques like ELISA, Western blot, and immunohistochemistry. Recent studies explore ITIH2 as a potential biomarker for disease progression or therapeutic response. However, its complex formation with other ITIH members and post-translational modifications pose challenges for antibody specificity, requiring careful validation in experimental settings. Ongoing research continues to clarify ITIH2's dual roles in physiological maintenance and disease mechanisms.
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