| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 126 kDa FK506-binding protein, 126 kDa FKBP, FKBP-126, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP126, Rotamase, h-FKBP-12, FKBP1B, FKBP126, FKBP1L, FKBP9, OTK4 |
| Entrez GeneID | 2281 |
| WB Predicted band size | 11.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FKBP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human FKBP1B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于FKBP1B (N-term)抗体的3篇参考文献示例(注：以下为假设性示例，实际文献需根据具体数据库检索)：
1. **文献名称**：*FKBP1B N-terminal antibody characterization in cardiac tissue*
**作者**：Smith A, et al.
**摘要**：该研究验证了FKBP1B (N-term)抗体在小鼠心肌组织中的特异性，证实其通过Western blot检测到25 kDa的条带，并用于免疫荧光定位FKBP1B在心肌细胞肌浆网的表达。
2. **文献名称**：*Role of FKBP1B in calcium regulation: Insights from N-terminal-specific antibody*
**作者**：Lee C, et al.
**摘要**：利用FKBP1B (N-term)抗体进行免疫共沉淀实验，发现FKBP1B通过N端结构域与兰尼碱受体(RyR2)相互作用，调控细胞内钙离子稳态。
3. **文献名称**：*Development and application of a novel FKBP1B antibody for neurodegenerative disease models*
**作者**：Garcia R, et al.
**摘要**：报道了一种高灵敏度的FKBP1B N端抗体，用于阿尔茨海默病模型大鼠脑组织分析，揭示FKBP1B表达水平与tau蛋白异常磷酸化的相关性。
如需实际文献，建议通过PubMed或Google Scholar以“FKBP1B antibody N-term”为关键词检索。
The FKBP1B (N-term) antibody is a reagent designed to target the N-terminal region of FKBP1B (FK506-binding protein 1B), a member of the immunophilin protein family. FKBP1B, also known as FKBP12.6. is a 12 kDa protein that binds immunosuppressant drugs like FK506 and rapamycin. It functions as a peptidyl-prolyl cis-trans isomerase (PPIase), aiding in protein folding and modulating intracellular signaling pathways. FKBP1B is particularly noted for its role in regulating calcium release channels, such as the ryanodine receptor (RyR2) in cardiac and skeletal muscle, where it stabilizes channel activity and prevents calcium leakage, impacting muscle contraction and arrhythmia susceptibility.
The N-terminal-specific antibody allows researchers to distinguish FKBP1B from its closely related paralog, FKBP1A (FKBP12), which shares ~85% sequence identity but differs in tissue distribution and function. This antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study FKBP1B expression, localization, and interactions in physiological and pathological contexts, such as heart failure, neurodegenerative diseases, and cancer. Its specificity for the N-terminal region ensures minimal cross-reactivity, making it a critical tool for elucidating FKBP1B's distinct roles in cellular processes and disease mechanisms.
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