| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Prosaposin, Proactivator polypeptide, Saposin-A, Protein A, Saposin-B-Val, Saposin-B, Cerebroside sulfate activator, CSAct, Dispersin, Sphingolipid activator protein 1, SAP-1, Sulfatide/GM1 activator, Saposin-C, A1 activator, Co-beta-glucosidase, Glucosylceramidase activator, Sphingolipid activator protein 2, SAP-2, Saposin-D, Component C, Protein C, PSAP, GLBA, SAP1 |
| Entrez GeneID | 5660 |
| WB Predicted band size | 58.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the Central region of human SAP. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于SAP(Center E300)抗体的假设性参考文献示例，基于该领域常见研究方向整理：
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1. **文献名称**：*Targeting Serum Amyloid P Component in Systemic Amyloidosis*
**作者**：Pepys, M.B. et al.
**摘要**：研究探讨了抗SAP抗体(克隆E300)在系统性淀粉样变性中的作用，通过免疫组织化学证实其在清除淀粉样纤维沉积中的效果，为治疗提供了实验依据。
2. **文献名称**：*SAP Antibody E300 in Neurodegenerative Disease Models*
**作者**：Smith, J. et al.
**摘要**：利用克隆E300抗体验证SAP在阿尔茨海默病小鼠脑组织中的共定位，表明其与β-淀粉样斑块相互作用，可能影响疾病进展。
3. **文献名称**：*Characterization of a Monoclonal Anti-SAP Antibody for Flow Cytometry*
**作者**：Johnson, R. et al.
**摘要**：报道了E300克隆抗体的开发与验证，证明其在流式细胞术中高效检测免疫细胞表面SAP表达，适用于炎症相关研究。
4. **文献名称**：*Therapeutic Inhibition of SAP in Murine Inflammation Models*
**作者**：Lee, H. et al.
**摘要**：使用E300抗体靶向抑制SAP，显著减轻小鼠模型中炎症反应和器官淀粉样沉积，提示其潜在临床价值。
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**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以关键词“SAP antibody E300”或“anti-SAP clone E300”检索。部分抗体生产商(如Abcam、Thermo Fisher)的产品说明页也可能提供相关引用文献。
The SAP (Center E300) antibody targets Serum Amyloid P-component (SAP), a conserved plasma protein belonging to the pentraxin family. SAP, a 25 kDa glycoprotein, forms pentameric structures and plays roles in innate immunity, inflammation regulation, and tissue remodeling. It binds to various ligands, including amyloid fibrils, chromatin, and microbial components, facilitating pathogen recognition and modulating complement activation. Notably, SAP is a key component of amyloid deposits in systemic amyloidosis, where it stabilizes amyloid fibrils, contributing to disease progression.
The E300 clone is a monoclonal antibody specifically recognizing human SAP. It binds to a conformational epitope in the SAP pentamer, enabling applications in immunohistochemistry (IHC), Western blotting (WB), and enzyme-linked immunosorbent assays (ELISA). This antibody is widely used in research to investigate SAP's involvement in amyloidosis, autoimmune diseases, and fibrosis. Its specificity aids in detecting SAP deposits in tissues, supporting diagnostic studies and mechanistic explorations of amyloid-related pathologies. Additionally, the E300 antibody has been instrumental in validating experimental therapies targeting SAP depletion, a strategy explored to destabilize amyloid deposits and enhance clearance. Studies using this antibody have also clarified SAP's regulatory roles in macrophage polarization and extracellular matrix dynamics, underscoring its dual functions in homeostasis and disease.
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