| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Peptidyl-prolyl cis-trans isomerase FKBP10, PPIase FKBP10, 65 kDa FK506-binding protein, 65 kDa FKBP, FKBP-65, FK506-binding protein 10, FKBP-10, Immunophilin FKBP65, Rotamase, FKBP10, FKBP65 |
| Entrez GeneID | 60681 |
| WB Predicted band size | 64.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FKBP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 552-580 amino acids from the C-terminal region of human FKBP10. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于FKBP10抗体的参考文献及摘要概括：
1. **"Mutations in FKBP10 cause recessive osteogenesis imperfecta and Bruck syndrome"**
- **作者**：Barnes AM, et al.
- **摘要**：该研究通过基因分析发现FKBP10突变导致隐性成骨不全症和Bruck综合征，FKBP10抗体用于检测患者成纤维细胞中FKBP65蛋白表达缺失，揭示其参与胶原交联的关键作用。
2. **"FKBP10 regulates lung fibroblast collagen synthesis through interaction with HSP47"**
- **作者**：Ishikawa Y, et al.
- **摘要**：研究利用FKBP10抗体进行免疫共沉淀和免疫荧光实验，发现FKBP10与HSP47互作调控肺纤维化中胶原合成，为纤维化治疗提供新靶点。
3. **"FKBP65 maintains proteostasis in collagen biosynthesis via chaperone-mediated autophagy"**
- **作者**：Choi JW, et al.
- **摘要**：通过FKBP10抗体抑制实验，揭示FKBP65通过分子伴侣介导的自噬机制维持胶原蛋白稳态，其缺陷导致内质网应激和细胞凋亡。
4. **"FKBP10 contributes to extracellular matrix organization in dermal fibroblasts"**
- **作者**：Cabral WA, et al.
- **摘要**：使用FKBP10抗体进行Western blot和免疫组化分析，证明FKBP10缺失导致真皮成纤维细胞胶原分泌异常，影响皮肤和骨骼ECM结构。
这些研究均通过FKBP10抗体探讨了该蛋白在疾病机制和分子通路中的功能，涵盖遗传病、纤维化及细胞代谢等领域。
FKBP10 antibody targets FK506-binding protein 10 (FKBP10), a member of the FKBP family of immunophilins that play roles in protein folding, cellular signaling, and stress response. FKBP10. also known as FKBP65. is a 65 kDa endoplasmic reticulum (ER)-resident chaperone protein. It binds collagen precursors via its peptidyl-prolyl isomerase (PPIase) domain, facilitating proper folding, stabilization, and post-translational modification of procollagen molecules. Dysregulation of FKBP10 is linked to osteogenesis imperfecta (OI) type XI and Bruck syndrome, rare genetic disorders characterized by brittle bones, joint contractures, and collagen cross-linking defects.
FKBP10 antibodies are essential tools for studying collagen biosynthesis, ER stress pathways, and connective tissue disorders. They are used in Western blotting, immunofluorescence, and immunohistochemistry to detect FKBP10 expression in tissues like bone, skin, and lung. Research applications include investigating FKBP10's role in fibrosis, cancer metastasis (e.g., modulating TGF-β signaling), and its potential as a therapeutic target. Commercial antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout models to ensure specificity. Recent studies also explore FKBP10 inhibitors for treating collagen-related pathologies, emphasizing its biomedical relevance.
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