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Rabbit Polyclonal PSME2 Antibody

  • 中文名: PSME2抗体
  • 别    名: Proteasome activator complex subunit 2, 11S regulator complex subunit beta, REG-beta, Activator of multicatalytic protease subunit 2, Proteasome activator 28 subunit beta, PA28b, PA28beta, PSME2
货号: IPDX30386
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProteasome activator complex subunit 2, 11S regulator complex subunit beta, REG-beta, Activator of multicatalytic protease subunit 2, Proteasome activator 28 subunit beta, PA28b, PA28beta, PSME2
Entrez GeneID5721
WB Predicted band size27.4kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis PSME2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-239 amino acids from the C-terminal region of human PSME2.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于PSME2抗体的3篇参考文献示例(内容为模拟概括,非真实文献):

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1. **文献名称**: *PSME2 Expression Correlates with Glioblastoma Immune Microenvironment*

**作者**: Zhang L, et al.

**摘要**: 本研究通过免疫组化(使用抗PSME2抗体)分析胶质母细胞瘤组织中PSME2蛋白的表达,发现其高表达与肿瘤相关巨噬细胞浸润及患者预后不良显著相关,提示PSME2可能通过调节肿瘤微环境促进免疫逃逸。

2. **文献名称**: *PSME2 as a Biomarker in HPV-Associated Cervical Cancer*

**作者**: Kim S, et al.

**摘要**: 利用抗PSME2抗体进行Western blot和免疫荧光检测,发现HPV阳性宫颈癌组织中PSME2表达上调,且与病毒癌蛋白E6/E7介导的蛋白酶体激活通路相关,可能成为治疗靶点。

3. **文献名称**: *Autoantibody Targeting PSME2 in Rheumatoid Arthritis*

**作者**: Müller R, et al.

**摘要**: 通过ELISA和免疫沉淀(使用重组PSME2蛋白及特异性抗体)发现,类风湿性关节炎患者血清中存在抗PSME2自身抗体,其滴度与疾病活动度正相关,表明PSME2异常免疫反应参与疾病进展。

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如需真实文献,建议在PubMed或Web of Science中检索关键词“PSME2 antibody”或“PA28β antibody”,并筛选涉及该抗体在疾病机制、诊断或治疗中的应用研究。

背景信息

The proteasome activator complex subunit 2 (PSME2), also known as PA28β, is a key component of the 11S regulatory particle that modulates the activity of the 20S proteasome, a central protease responsible for degrading ubiquitinated proteins. PSME2 forms a heterohexameric complex with PSME1 (PA28α) or PSME3 (PA28γ) to enhance proteasomal cleavage efficiency, particularly in generating antigenic peptides for major histocompatibility complex (MHC) class I presentation. This process is critical for adaptive immune responses. PSME2 is broadly expressed, with elevated levels observed in immune-related tissues and certain cancers. Antibodies targeting PSME2 are essential tools for studying proteasome regulation, protein turnover dynamics, and immune evasion mechanisms in diseases. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess PSME2 expression patterns. Research has linked PSME2 dysregulation to tumor progression, neurodegenerative disorders, and autoimmune conditions, highlighting its dual roles in maintaining proteostasis and modulating inflammatory pathways. Recent studies also explore PSME2's potential as a therapeutic target or biomarker in cancer immunotherapy, given its influence on antigen processing and T-cell activation. Commercial PSME2 antibodies are typically validated for specificity against human, mouse, or rat homologs, with applications spanning basic research and preclinical investigations.

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