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Rabbit Polyclonal AK7 Antibody

  • 中文名: AK7抗体
  • 别    名: Adenylate kinase 7, AK 7, ATP-AMP transphosphorylase 7, AK7
货号: IPDX30313
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAdenylate kinase 7, AK 7, ATP-AMP transphosphorylase 7, AK7
Entrez GeneID122481
WB Predicted band size82.7kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis AK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 629-656 amino acids from the C-terminal region of human AK7.
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于AK7抗体的虚构参考文献示例(注:以下内容为模拟生成,非真实文献,仅供格式参考):

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1. **文献名称**: "AK7 Antibody Targets Tumor-Specific Antigens in Colorectal Cancer"

**作者**: Smith J, et al.

**摘要**: 本研究开发了一种新型AK7单克隆抗体,通过靶向结直肠癌细胞表面特异性抗原,在小鼠模型中显著抑制肿瘤生长。实验表明,AK7抗体通过激活ADCC(抗体依赖的细胞毒性)途径增强免疫应答。

2. **文献名称**: "Structural Characterization of AK7 Antibody Epitopes Using Cryo-EM"

**作者**: Chen L, et al.

**摘要**: 利用冷冻电镜技术解析了AK7抗体与其靶蛋白的结合表位,揭示了抗体-抗原相互作用的关键氨基酸残基,为优化AK7的治疗潜力提供了结构基础。

3. **文献名称**: "AK7 Antibody-Based Detection of Neurodegenerative Biomarkers in CSF"

**作者**: Müller R, et al.

**摘要**: 开发了一种基于AK7抗体的ELISA检测方法,用于定量脑脊液中的tau蛋白磷酸化形式。该方法在阿尔茨海默病早期诊断中显示出高灵敏度和特异性。

4. **文献名称**: "AK7 Antibody Cross-Reactivity Analysis in Autoimmune Disease Models"

**作者**: Tanaka K, et al.

**摘要**: 评估了AK7抗体在类风湿性关节炎模型中的交叉反应性,发现其对特定炎症细胞因子具有中和作用,提示其在自身免疫疾病治疗中的潜在应用。

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**提示**:以上文献为虚构示例,如需真实文献,建议通过PubMed、Google Scholar等平台搜索关键词(如“AK7 antibody”或“AK7+[疾病/技术]”),并筛选近年高被引论文。

背景信息

The AK7 antibody targets adenylate kinase 7 (AK7), a mitochondrial enzyme involved in cellular energy metabolism by catalyzing the reversible transfer of phosphate groups between nucleotides (e.g., AMP + ATP ↔ 2 ADP). AK7 plays a critical role in maintaining nucleotide homeostasis, particularly in energy-demanding tissues like sperm flagella, where its dysfunction has been linked to reduced sperm motility and male infertility. Recent studies also associate AK7 with cancer progression; for example, its downregulation in colorectal cancer correlates with poor prognosis, suggesting a tumor-suppressive role. Additionally, AK7 mutations have been implicated in neurodegenerative disorders, such as Parkinson’s disease, possibly due to impaired mitochondrial function. The AK7 antibody is widely used as a research tool to detect protein expression levels via techniques like Western blotting or immunohistochemistry, aiding investigations into its biological roles and disease mechanisms. Its clinical relevance is emerging, with potential applications as a biomarker or therapeutic target in fertility disorders, cancer, and neurodegenerative conditions. Further research is needed to fully elucidate AK7's signaling pathways and therapeutic potential.

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