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Rabbit Polyclonal HDBP2(HDRF-2) Antibody

  • 中文名: HDBP2(HDRF-2)抗体
  • 别    名: Zinc finger protein 395, HD-regulating factor 2, HDRF-2, Huntington disease gene regulatory region-binding protein 2, HD gene regulatory region-binding protein 2, HDBP-2, Papillomavirus regulatory factor 1, PRF-1, Papillomavirus-binding factor, ZNF395, HD
货号: IPDX30290
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZinc finger protein 395, HD-regulating factor 2, HDRF-2, Huntington disease gene regulatory region-binding protein 2, HD gene regulatory region-binding protein 2, HDBP-2, Papillomavirus regulatory factor 1, PRF-1, Papillomavirus-binding factor, ZNF395, HDBP2, PBF
Entrez GeneID55893
WB Predicted band size54.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis HDBP2(HDRF-2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-170 amino acids from the Central region of human HDBP2(HDRF-2).
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于HDBP2(HDRF-2)抗体的3篇参考文献示例(注:文献为模拟示例,实际引用需核实):

1. **"Characterization of HDBP2 as a DNA Repair Factor Using a Novel Polyclonal Antibody"**

- **作者**: Zhang et al. (2018)

- **摘要**: 本研究开发了一种针对HDBP2的多克隆抗体,验证了其在Western blot和免疫荧光中的特异性,证实HDBP2在DNA损伤修复过程中与BRCA1复合物相互作用,并调控细胞周期检查点。

2. **"HDRF-2 Antibody Reveals Elevated Expression in Glioblastoma Tissues"**

- **作者**: Thompson et al. (2020)

- **摘要**: 通过免疫组化分析,发现HDRF-2在胶质母细胞瘤中高表达,并与患者预后不良相关。研究使用商业化HDRF-2抗体(克隆号:ABX-102),验证了抗体在肿瘤样本中的特异性染色。

3. **"Functional Analysis of HDBP2 in Neuronal Differentiation via CRISPR/Cas9 and Antibody-Based Knockdown"**

- **作者**: Lee & Kim (2019)

- **摘要**: 利用HDBP2抗体(兔源单抗,货号:sc-555)结合siRNA技术,揭示了HDBP2通过调控表观遗传修饰因子(如HDACs)促进神经元分化的机制,抗体特异性经敲除细胞系验证。

**提示**:实际文献需通过PubMed、Google Scholar或抗体供应商官网(如Cell Signaling、Abcam)提供的引用信息查询。建议根据具体实验需求选择经过验证的抗体及相关研究。

背景信息

The HDBP2 (HDRF-2) antibody targets the Homology-Directed Repair Factor 2 (HDRF-2), a protein involved in DNA damage repair through the homology-directed repair (HDR) pathway. HDRF-2. also known as BRCA1-associated protein or BCCIP in some contexts, plays a critical role in maintaining genomic stability by facilitating error-free repair of DNA double-strand breaks (DSBs). It interacts with key repair proteins like BRCA1. BRCA2. and RAD51. enhancing their functions in DNA recombination and replication stress response. Dysregulation of HDRF-2 is linked to genomic instability, cancer progression, and chemoresistance, particularly in BRCA-mutant cancers.

The HDBP2 antibody is widely used in research to study HDR mechanisms, protein expression patterns, and subcellular localization via techniques like Western blotting, immunofluorescence, and immunohistochemistry. It helps identify HDRF-2's role in tumorigenesis and therapeutic responses, especially in cancers reliant on HDR pathways (e.g., breast, ovarian, and pancreatic cancers). Additionally, this antibody aids in exploring HDRF-2 as a potential biomarker for predicting treatment outcomes or as a target for synthetic lethality strategies in precision oncology. Its specificity and reliability make it a vital tool for understanding DNA repair dynamics and developing targeted cancer therapies.

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