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Rabbit Polyclonal ABL2(R432) Antibody

  • 中文名： ABL2 (R432)抗体
  • 别    名： Abelson tyrosine-protein kinase 2, Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine-protein kinase ARG, ABL2, ABLL, ARG
货号: IPDX30260
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesAPC3; HNUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E;
Entrez GeneID996
clone5C12
WB Predicted band size91kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CDC27 expressed in E. Coli.  
FormulationAscitic fluid containing 0.03% sodium azide.

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参考文献

以下是关于ABL2 (R432)抗体的虚构参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询确认)：

1. **文献名称**：**"Development and characterization of a monoclonal antibody targeting ABL2 kinase domain (R432 epitope) for cancer research"**

**作者**：Smith J, et al.

**摘要**：本研究报道了一种针对ABL2激酶结构域R432表位的高特异性单克隆抗体的开发。该抗体通过Western blot和免疫组化验证，可特异性识别ABL2蛋白，且在乳腺癌和肺癌细胞系中检测到ABL2的异常表达，提示其在肿瘤信号通路研究中的应用潜力。

2. **文献名称**：**"ABL2 phosphorylation at residue R432 regulates cell motility and invasion in metastatic colorectal cancer"**

**作者**：Chen L, et al.

**摘要**：文章利用R432抗体探究ABL2在结直肠癌转移中的作用。实验表明，R432位点的磷酸化状态通过调控细胞骨架重组促进癌细胞迁移，抗体特异性阻断该位点可显著抑制体外侵袭能力，为靶向治疗提供依据。

3. **文献名称**：**"A comparative study of commercial antibodies for ABL2 detection: Focus on clone R432 sensitivity and specificity"**

**作者**：Wang Y, et al.

**摘要**：本研究评估了多种市售ABL2抗体的性能，发现R432克隆号抗体在流式细胞术和免疫荧光中表现出高灵敏度和低交叉反应性，优于其他同类产品，推荐其在基础研究中的广泛应用。

4. **文献名称**：**"Role of ABL2 in neuronal development: Insights from R432-targeted antibody perturbation experiments"**

**作者**：Garcia R, et al.

**摘要**：通过使用R432抗体干扰ABL2功能，研究发现ABL2在神经元突触形成中起关键作用，其活性缺失导致小鼠皮层神经元轴突导向异常，揭示了ABL2在神经系统发育中的新机制。

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**提示**：实际文献需通过PubMed、Google Scholar等平台以关键词“ABL2 antibody R432”或“ABL2 epitope R432”检索，或查阅抗体供应商(如CST、Abcam)提供的产品引用文献列表。

背景信息

The ABL2 (R432) antibody is a specific immunological tool designed to detect the ABL2 tyrosine kinase, also known as Abelson-related gene (ARG). ABL2. part of the Abelson (ABL) kinase family, plays critical roles in cellular processes such as cytoskeletal remodeling, cell motility, and signaling pathways regulating proliferation and survival. Unlike its homolog ABL1. which is well-studied in leukemia (e.g., BCR-ABL fusion in CML), ABL2 is more prominently associated with solid tumors, particularly in cancers exhibiting metastatic behavior or drug resistance. The R432 epitope corresponds to a region within the kinase domain of ABL2. enabling the antibody to recognize both native and phosphorylated forms, depending on its design. This antibody is commonly used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ABL2 expression, activation, or localization in cell lines, tissues, or preclinical models. Researchers employ it to explore ABL2's involvement in oncogenic signaling, epithelial-mesenchymal transition (EMT), and interactions with downstream effectors like CRK and CRKL. Its specificity for ABL2 over ABL1 makes it valuable for dissecting isoform-specific functions in cancer biology and developmental studies. Host species (e.g., rabbit or mouse) and clonality (monoclonal/polyclonal) may vary by vendor, requiring validation for experimental contexts.

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