| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ubiquitin carboxyl-terminal hydrolase 21, Deubiquitinating enzyme 21, Ubiquitin thioesterase 21, Ubiquitin-specific-processing protease 21, USP21, USP23 |
| Entrez GeneID | 27005 |
| WB Predicted band size | 62.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This USP21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 226-256 amino acids from the Central region of human USP21. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于USP21抗体的3篇文献示例(虚构内容，供参考)：
1. **文献名称**：*USP21 deubiquitinates and stabilizes STAT5 to promote tumor progression in breast cancer*
**作者**：Li X, Chen Y, et al.
**摘要**：该研究利用USP21抗体通过免疫共沉淀和Western blot分析，揭示了USP21通过去泛素化STAT5增强其稳定性，促进乳腺癌细胞增殖和转移的分子机制。
2. **文献名称**：*USP21 regulates antiviral responses by deubiquitinating RIG-I in innate immunity*
**作者**：Wang H, Zhang L, et al.
**摘要**：研究通过USP21抗体检测其在病毒感染细胞中的表达定位，发现USP21通过去泛素化RIG-I负调控I型干扰素信号通路，为抗病毒免疫调控提供新靶点。
3. **文献名称**：*Development and validation of a specific USP21 monoclonal antibody for neurodegenerative disease studies*
**作者**：Smith J, Brown K, et al.
**摘要**：该文献报道了一种高特异性USP21单克隆抗体的开发及验证，并应用于阿尔茨海默病模型小鼠脑组织分析，证实USP21异常表达与tau蛋白聚集相关。
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注：以上内容为模拟示例，实际文献需通过PubMed/Google Scholar等平台检索关键词“USP21 antibody”或“USP21 function”获取。
The USP21 antibody is a crucial tool for studying ubiquitin-specific protease 21 (USP21), a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease family. USP21 regulates protein stability, localization, and function by cleaving ubiquitin chains from substrate proteins, thereby counteracting ubiquitin-mediated degradation or signaling. It plays roles in diverse biological processes, including immune response regulation, cell cycle progression, and apoptosis. USP21 has been implicated in modulating key signaling pathways such as NF-κB and Wnt/β-catenin, and it interacts with substrates like RIPK1. β-catenin, and BRD4. Dysregulation of USP21 is associated with cancers, inflammatory diseases, and neurodegenerative disorders.
USP21 antibodies are widely used in research to detect and quantify USP21 expression via techniques like Western blotting, immunoprecipitation, and immunofluorescence. They help elucidate USP21's tissue distribution, subcellular localization, and interaction networks. High-quality USP21 antibodies exhibit specificity and sensitivity, often validated using knockout cell lines or siRNA-mediated knockdown. Researchers also employ these antibodies to explore USP21's therapeutic potential, as targeting DUBs like USP21 could offer novel strategies for treating diseases linked to ubiquitination defects. Overall, USP21 antibodies are indispensable for advancing our understanding of USP21's biological roles and its relevance to human health.
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