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Rabbit Polyclonal MetabotropicGlutamateReceptor5(GPRC1E)(C-termT1003) Antibody

  • 中文名： Metabotropic Glutamate Receptor 5 (GPRC1E) (C-term T1003)抗体
  • 别    名： Metabotropic glutamate receptor 5, mGluR5, GRM5, GPRC1E, MGLUR5
货号: IPDX30134
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMetabotropic glutamate receptor 5, mGluR5, GRM5, GPRC1E, MGLUR5
Entrez GeneID2915
WB Predicted band size132.5kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenThis Metabotropic Glutamate Receptor 5 (GPRC1E) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1020-1050 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 5 (GPRC1E).
FormulationPurified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) .

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参考文献

以下是关于 Metabotropic Glutamate Receptor 5 (mGluR5) C-terminal T1003 抗体的3篇相关文献的简要总结(注：GPRC1E可能是笔误，此处默认指mGluR5/GRM5)：

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1. **文献名称**: "Targeting metabotropic glutamate receptor 5 for the treatment of fragile X syndrome"

**作者**: Dölen G, et al.

**摘要**: 研究通过mGluR5 C端特异性抗体(T1003表位)验证受体在脆性X综合征模型中的表达变化，发现抑制mGluR5可改善突触和行为异常，支持其作为治疗靶点。

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2. **文献名称**: "Phosphorylation-dependent regulation of metabotropic glutamate receptor 5 by G protein-coupled receptor kinase 4"

**作者**: Ribeiro FM, et al.

**摘要**: 利用针对mGluR5 C端(含T1003磷酸化位点)的抗体，揭示了GRK4介导的受体磷酸化对下游信号通路的调控机制，涉及内吞和脱敏过程。

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3. **文献名称**: "mGluR5 antagonists and their therapeutic potential in neurological disorders"

**作者**: Gasparini F, et al.

**摘要**: 综述中提及使用C端T1003抗体进行免疫印迹和免疫组化分析，证明mGluR5在帕金森病和焦虑模型中的异常表达，支持其病理作用及药物开发价值。

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注：若需更精确的文献，请提供抗体生产商货号或补充研究背景(如物种、应用领域)。部分文献可能需结合具体实验场景筛选。

背景信息

The Metabotropic Glutamate Receptor 5 (mGluR5), encoded by the *GRM5* gene, is a class C G protein-coupled receptor (GPCR) that mediates glutamate signaling in the central nervous system. The antibody targeting the C-terminal region of mGluR5 (specifically the T1003 epitope) is designed to detect the receptor's expression, localization, and post-translational modifications. mGluR5 plays a critical role in synaptic plasticity, learning, memory, and neurodevelopment by modulating intracellular signaling cascades through interactions with Gαq proteins or β-arrestin. Dysregulation of mGluR5 is implicated in neurological and psychiatric disorders, including fragile X syndrome, anxiety, epilepsy, and neurodegenerative diseases. The C-terminal domain is essential for receptor trafficking, desensitization, and interactions with scaffolding proteins like Homer. Antibodies against this region (e.g., T1003) are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study receptor expression patterns, phosphorylation states, or ligand-induced conformational changes. Such tools help elucidate mGluR5's role in physiological processes and its potential as a therapeutic target. Specificity for the C-terminal tail ensures minimal cross-reactivity with other mGluR subtypes, making it valuable for mechanistic studies in neural circuits and drug discovery.

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