| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Uncharacterized aarF domain-containing protein kinase 5, 2711-, ADCK5 |
| Entrez GeneID | 203054 |
| WB Predicted band size | 65.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADCK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 434-464 amino acids from the C-terminal region of human ADCK5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于ADCK5抗体的示例性参考文献(注：以下内容为模拟示例，实际文献可能需要通过学术数据库检索确认)：
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1. **文献名称**：*ADCK5 regulates mitochondrial function through CoQ biosynthesis in human cells*
**作者**：Smith J, Brown K, et al.
**摘要**：本研究利用ADCK5特异性抗体，通过Western blot和免疫荧光技术，揭示了ADCK5蛋白在线粒体中的定位及其通过调控辅酶Q(CoQ)生物合成影响细胞能量代谢的机制。
2. **文献名称**：*Expression profiling of ADCK5 in colorectal cancer and its association with tumor progression*
**作者**：Zhang L, Wang H, et al.
**摘要**：通过免疫组化(IHC)和ADCK5抗体分析结直肠癌组织样本，发现ADCK5在肿瘤组织中显著高表达，且与患者预后不良相关，提示其可能作为潜在生物标志物。
3. **文献名称**：*ADCK5 interacts with PINK1/Parkin in mitophagy: Implications for neurodegenerative diseases*
**作者**：Lee S, Kim M, et al.
**摘要**：研究通过免疫共沉淀(Co-IP)和ADCK5抗体验证了ADCK5与PINK1/Parkin通路的相互作用，表明其在神经退行性疾病中线粒体自噬(mitophagy)过程中的调控作用。
4. **文献名称**：*Development and validation of a polyclonal antibody against human ADCK5 for functional studies*
**作者**：Johnson R, Patel S, et al.
**摘要**：报道了一种兔源多克隆ADCK5抗体的开发，并通过质谱和敲除细胞系验证其特异性，为后续ADCK5蛋白的功能研究提供了可靠工具。
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如需真实文献，建议在 **PubMed** 或 **Web of Science** 中检索关键词“ADCK5 antibody”或“ADCK5 protein”，并筛选涉及该抗体应用的实验研究。
The ADCK5 antibody is a research tool designed to detect and study the AarF domain-containing kinase 5 (ADCK5), a protein belonging to the UBIAD1 family. ADCK5. also known as Coq8B, is implicated in cellular energy metabolism, particularly in the biosynthesis of coenzyme Q (CoQ), a critical component of the mitochondrial electron transport chain. Unlike its paralog ADCK3/Coq8A, which is directly involved in CoQ synthesis, ADCK5's precise role remains less defined but is suggested to regulate enzyme stability or activity in CoQ-related pathways. It localizes to mitochondria-associated membranes and may influence lipid metabolism and oxidative stress responses.
Research using ADCK5 antibodies has focused on elucidating its expression patterns, interactions, and potential involvement in diseases such as neurodegenerative disorders, metabolic syndromes, and cancer. These antibodies, often raised in rabbits or mice, are validated for applications like Western blotting, immunofluorescence, and immunoprecipitation. Recent studies highlight ADCK5's possible crosstalk with signaling pathways like Wnt or mTOR, linking it to cellular growth and survival mechanisms. However, its functional redundancy with other ADCK family members and tissue-specific roles warrant further investigation. Reliable ADCK5 antibodies are essential for advancing understanding of its biological significance and therapeutic potential.
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