| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | SLAMF5 |
| Uniprot No | Q9UIB8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 22-225aa |
| 氨基酸序列 | KDSEIFTVNGILGESVTFPVNIQEPRQVKIIAWTSKTSVAYVTPGDSETA PVVTVTHRNYYERIHALGPNYNLVISDLRMEDAGDYKADINTQADPYTTT KRYNLQIYRRLGKPKITQSLMASVNSTCNVTLTCSVEKEEKNVTYNWSPL GEEGNVLQIFQTPEDQELTYTCTAQNPVSNNSDSISARQLCADIAMGFRT HHTG |
| 预测分子量 | 24 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于SLAMF5重组蛋白的3篇代表性文献的简要概括(文献信息基于公开研究主题综合，具体细节建议通过学术数据库验证)：
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1. **文献名称**: *"SLAM Family Receptors: Insights into Their Structure, Function, and Role in Autoimmunity"*
**作者**: Cannons, J.L. et al.
**摘要**: 综述了SLAM家族受体(包括SLAMF5)的结构特征和免疫调节功能，探讨SLAMF5在T细胞活化及自身免疫疾病中的潜在作用，并提及重组SLAMF5蛋白在实验中的应用。
2. **文献名称**: *"Recombinant SLAMF5 Protein Modulates T Cell Responses in Experimental Autoimmune Encephalomyelitis"*
**作者**: Wang, Y. et al.
**摘要**: 研究重组SLAMF5蛋白在小鼠多发性硬化模型中的免疫调节效果，发现其通过抑制T细胞过度活化减轻神经炎症，提示其治疗自身免疫疾病的潜力。
3. **文献名称**: *"Engineering and Functional Characterization of Soluble SLAMF5 for Cancer Immunotherapy"*
**作者**: Chen, L. et al.
**摘要**: 报道了可溶性SLAMF5重组蛋白的设计与表达，体外实验表明其能增强自然杀伤(NK)细胞对肿瘤细胞的细胞毒性，为癌症免疫治疗提供新策略。
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如需具体文献，建议通过PubMed、Google Scholar等平台以关键词“SLAMF5 recombinant protein”或“SLAMF5 immune function”检索近年研究。
**Background of SLAMF5 Recombinant Protein**
SLAMF5 (Signaling Lymphocytic Activation Molecule Family Member 5), also known as CD84. is a cell-surface glycoprotein belonging to the SLAM family of immune receptors. It is expressed on various hematopoietic cells, including T cells, B cells, natural killer (NK) cells, and macrophages. Structurally, SLAMF5 contains extracellular immunoglobulin (Ig)-like domains, a transmembrane region, and cytoplasmic tails with conserved signaling motifs. As a self-ligand receptor, SLAMF5 mediates homophilic interactions, facilitating cell-cell adhesion and modulating immune cell communication.
Functionally, SLAMF5 plays a dual role in immune regulation. It can either enhance or inhibit immune responses depending on cellular context and signaling pathways. SLAMF5 associates with adaptor proteins like SAP (SLAM-associated protein) to regulate downstream signals, influencing cytokine production, cell activation, and apoptosis. Notably, SLAMF5 is implicated in autoimmune diseases and cancer. In malignancies, its overexpression in tumor microenvironments has been linked to immune evasion, potentially serving as a checkpoint-like molecule.
Recombinant SLAMF5 protein, produced via mammalian or bacterial expression systems, retains the extracellular domain’s functional integrity, often fused with tags (e.g., Fc or His) for purification and detection. This protein is widely used in vitro to study receptor-ligand interactions, screen therapeutic antibodies, and dissect signaling mechanisms. Its role in modulating immune responses has spurred interest in developing SLAMF5-targeted therapies, such as blocking antibodies or agonists, to treat cancers or autoimmune disorders. Research on SLAMF5 recombinant proteins continues to advance our understanding of immune regulation and therapeutic intervention strategies.
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