| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PEBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCB7抗体的参考文献示例(内容为模拟概括，具体文献需通过学术数据库核实)：
1. **《ABCB7 regulates mitochondrial iron homeostasis and erythropoiesis》**
- **作者：Smith A, et al.**
- **摘要**：研究利用ABCB7抗体进行Western blot和免疫荧光分析，发现ABCB7在线粒体铁转运中起关键作用，其缺失导致红细胞发育异常及铁硫簇合成障碍。
2. **《Mutations in ABCB7 cause X-linked sideroblastic anemia》**
- **作者：Bekri S, et al.**
- **摘要**：通过免疫组化和抗体标记技术，揭示ABCB7基因突变导致线粒体铁积累，引发X连锁铁粒幼细胞性贫血，证实ABCB7在铁代谢中的功能。
3. **《ABCB7-mediated transport of heme precursors in mitochondria》**
- **作者：Chen Y, et al.**
- **摘要**：利用ABCB7抗体沉默细胞模型，证明该蛋白参与血红素前体跨线粒体膜运输，为相关血液疾病提供分子机制依据。
4. **《Proteomic analysis of ABCB7 interactions in mitochondrial membrane》**
- **作者：Tanaka K, et al.**
- **摘要**：结合免疫共沉淀(使用ABCB7抗体)和质谱技术，鉴定ABCB7在线粒体膜中的相互作用蛋白网络，强调其在细胞氧化应激反应中的作用。
建议通过PubMed或Google Scholar搜索最新文献，以“ABCB7 antibody”或“ABCB7 function”为关键词获取准确信息。
The ABCB7 antibody targets the ATP-binding cassette sub-family B member 7 (ABCB7), a mitochondrial membrane protein involved in cellular iron homeostasis. ABCB7 belongs to the evolutionarily conserved ATP-binding cassette (ABC) transporter family, which facilitates the transport of diverse substrates across biological membranes. Specifically, ABCB7 plays a critical role in the maturation and export of iron-sulfur (Fe-S) clusters from mitochondria to the cytosol, a process essential for numerous cellular functions, including enzyme activity, DNA repair, and redox regulation. Mutations in the ABCB7 gene are linked to X-linked sideroblastic anemia with ataxia (XLSA/A), a rare disorder characterized by mitochondrial iron overload and neurological impairments.
ABCB7 antibodies are widely used in research to study mitochondrial iron metabolism, Fe-S cluster biogenesis, and related pathologies. These antibodies enable the detection and quantification of ABCB7 protein expression via techniques like Western blotting, immunofluorescence, and immunohistochemistry. They also aid in elucidating ABCB7's interaction partners and regulatory mechanisms. Given its role in iron regulation, ABCB7 is a potential therapeutic target for disorders involving mitochondrial dysfunction or iron misdistribution. Commercially available ABCB7 antibodies are typically validated for specificity and cross-reactivity across human, mouse, and rat models, supporting translational research in hematology, neurobiology, and metabolic diseases.
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