| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | S100A13 |
| Uniprot No | Q99584 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-98aa |
| 氨基酸序列 | MGSSHHHHHHSSGLVPRGSHMAAEPLTELEESIETVVTTFFTFARQEGRK DSLSVNEFKELVTQQLPHLLKDVGSLDEKMKSLDVNQDSELKFNEYWRLI GELAKEIRKKKDLKIRKK |
| 预测分子量 | 14 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
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**Background of S100A13 Recombinant Protein**
S100A13 is a member of the S100 protein family, a group of small, calcium-binding proteins characterized by EF-hand structural motifs. These proteins regulate diverse cellular processes, including proliferation, differentiation, and apoptosis, by interacting with intracellular targets or extracellular receptors. S100A13. encoded by the *S100A13* gene on human chromosome 1q21. is unique for its role in non-classical secretion pathways, particularly in the release of fibroblast growth factor 1 (FGF1) and interleukin-1α (IL-1α), which lack traditional signal peptides.
Structurally, S100A13 forms homodimers or heterocomplexes with other S100 proteins, enabling calcium-dependent interactions with anionic phospholipids and partner proteins. Its ability to coordinate zinc and copper ions further modulates its function in oxidative stress responses and metal homeostasis. Studies highlight S100A13's involvement in pathological conditions, such as cancer (e.g., promoting angiogenesis in glioblastoma), cardiovascular diseases (e.g., myocardial infarction repair), and neurodegenerative disorders, likely due to its role in inflammation and tissue remodeling.
Recombinant S100A13 proteins, typically expressed in *E. coli* or mammalian systems, retain native folding and functionality, making them valuable tools for studying protein-protein interactions, secretion mechanisms, and therapeutic targeting. Their applications span *in vitro* assays, structural studies, and drug screening, particularly for diseases linked to dysregulated S100A13 expression. Ongoing research aims to elucidate its precise regulatory mechanisms and potential as a diagnostic biomarker or therapeutic target in inflammation-associated pathologies.
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