| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Macrophage metalloelastase; MME; 3.4.24.65; Macrophage elastase; ME; hME; Matrix metalloproteinase-12; MMP-12; MMP12; HME |
| Entrez GeneID | 4321 |
| WB Predicted band size | Calculated MW: 54 kDa; Observed MW: 54,45,22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthesized peptide derived from human MMP12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MMP12抗体的3篇文献信息(示例为模拟内容，实际引用需核实)：
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1. **文献名称**：*MMP12 inhibition reverses elastase-induced emphysema in mice*
**作者**：Shapiro SD, et al.
**摘要**：研究通过单克隆抗体靶向抑制MMP12的蛋白水解活性，成功逆转小鼠模型中弹性蛋白酶诱导的肺气肿病理特征，表明MMP12抗体在慢性肺病中的治疗潜力。
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2. **文献名称**：*Role of MMP12 in atherosclerosis and its neutralization by antibody therapy*
**作者**：Johnson JL, et al.
**摘要**：发现MMP12促进动脉粥样硬化斑块不稳定性，使用特异性抗体阻断MMP12可减少斑块内炎症细胞浸润及基质降解，为心血管疾病提供新干预策略。
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3. **文献名称**：*Anti-MMP12 antibody attenuates lung inflammation in COPD models*
**作者**：Churg A, et al.
**摘要**：在香烟烟雾暴露的小鼠模型中，抗MMP12抗体显著降低肺部炎症介质水平及巨噬细胞活化，证实MMP12在COPD相关炎症中的关键作用及抗体治疗的有效性。
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(注：以上内容为示例，实际文献需通过PubMed、Web of Science等平台检索关键词“MMP12 antibody”或“MMP12 inhibitor”获取。)
Matrix metalloproteinase 12 (MMP12), also known as macrophage metalloelastase, is a member of the zinc-dependent endopeptidase family involved in extracellular matrix (ECM) remodeling. Primarily secreted by macrophages, MMP12 specifically degrades elastin, fibronectin, and other ECM components, playing critical roles in physiological processes like tissue repair and pathological conditions such as chronic obstructive pulmonary disease (COPD), atherosclerosis, and cancer metastasis. Its overexpression is linked to destructive inflammatory diseases, particularly in lung tissue, where it contributes to emphysema by breaking down alveolar structures.
MMP12 antibodies are essential tools for detecting and quantifying MMP12 expression in research and diagnostics. These antibodies enable the study of MMP12's spatial and temporal distribution in tissues, its regulation under inflammatory stimuli, and its interaction with inhibitors like TIMPs (tissue inhibitors of metalloproteinases). They are widely used in techniques such as Western blotting, immunohistochemistry, and ELISA to explore MMP12's role in disease mechanisms. Additionally, therapeutic MMP12-neutralizing antibodies are under investigation to mitigate ECM degradation in conditions like COPD and abdominal aortic aneurysms. However, challenges remain in ensuring antibody specificity due to structural similarities among MMP family members. Validated MMP12 antibodies are crucial for advancing both basic research and clinical applications targeting this protease.
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