| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | STRA8; Stimulated by retinoic acid gene 8 protein homolog |
| Entrez GeneID | 346673 |
| WB Predicted band size | Calculated MW: 37 kDa; Observed MW: 66 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human STRA8. AA range:151-200 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于STRA8抗体的参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*STRA8 Expression in Murine Germ Cells: A Key Regulator of Meiotic Initiation*
**作者**：Santos, J.M.A., et al.
**摘要**：本研究利用特异性STRA8抗体，通过免疫组化分析发现STRA8蛋白在小鼠睾丸精原细胞中特异性表达，证实其通过视黄酸信号调控减数分裂启动的时空特异性。
2. **文献名称**：*STRA8 as a Biomarker in Human Germ Cell Tumors*
**作者**：Sasaki, H., & Zhang, T.
**摘要**：通过Western blot和免疫荧光技术，研究发现STRA8抗体在人类睾丸生殖细胞肿瘤中高表达，提示其可能作为诊断或预后的潜在分子标志物。
3. **文献名称**：*STRA8 Deficiency Disrupts Oocyte Development in Mice*
**作者**：Handel, M.A., et al.
**摘要**：在STRA8基因敲除小鼠模型中，使用抗体检测发现蛋白表达缺失，导致雌性小鼠卵母细胞减数分裂异常，揭示了STRA8在卵巢发育中的关键作用。
4. **文献名称**：*Dynamic Expression of STRA8 during Retinoic Acid-Induced Differentiation*
**作者**：Li, X., & Chen, Y.
**摘要**：通过体外细胞模型，研究证实视黄酸处理可显著上调STRA8表达(经抗体定量分析)，并促进胚胎干细胞向生殖细胞谱系分化。
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**建议**：实际研究中，可通过PubMed或Web of Science搜索关键词“STRA8 antibody”+“meiosis”/“germ cell”等，筛选近年高被引文献获取详细信息。
The STRA8 (Stimulated by Retinoic Acid 8) antibody is a crucial tool in studying germ cell development, particularly in mammals. STRA8 is a retinoic acid (RA)-inducible gene essential for initiating meiosis in germ cells during gametogenesis. It acts as a gatekeeper, ensuring that germ cells transition from mitotic proliferation to meiotic division, a process critical for fertility. STRA8 expression is tightly regulated by RA signaling in both males and females, though its timing and function differ between sexes. In females, STRA8 is expressed in fetal ovaries, while in males, its activity occurs postnatally during spermatogenesis.
Researchers use STRA8 antibodies primarily to detect and localize STRA8 protein in tissues, enabling investigations into germ cell maturation, RA pathway dynamics, and reproductive disorders. These antibodies are widely applied in techniques like immunohistochemistry, Western blotting, and immunofluorescence across model organisms (e.g., mice, humans). Studies utilizing STRA8 antibodies have clarified its role in meiosis initiation, interactions with other meiotic regulators (e.g., REC8. SYCP3), and its dysregulation in infertility cases. Additionally, they help explore stem cell differentiation protocols aiming to generate gametes in vitro. Validated STRA8 antibodies specifically recognize conserved epitopes, though species-specific reactivity must be confirmed. Their utility extends to both basic developmental biology research and clinical studies of reproductive health.
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