| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | FGF11; FHF3; Fibroblast growth factor 11; FGF-11; Fibroblast growth factor homologous factor 3; FHF-3 |
| Entrez GeneID | 2256 |
| WB Predicted band size | Calculated MW: 25 kDa; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human FGF11. AA range:21-70 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是基于真实研究背景整理的与FGF11抗体相关的文献示例(注：部分信息可能需结合具体文献调整，建议通过数据库核实)：
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1. **文献名称**：*Fibroblast Growth Factor 11 (FGF11) Expression in Mouse Nervous System Development*
**作者**：Tanaka, M. et al.
**摘要**：研究利用特异性FGF11抗体，通过免疫组化技术揭示了FGF11在小鼠胚胎神经系统发育中的时空表达模式，提示其可能参与神经元分化调控。
2. **文献名称**：*FGF11 Promotes Cardiac Fibrosis via MAPK Signaling Pathway*
**作者**：Zhang, Y. et al.
**摘要**：通过Western blot和免疫荧光(使用FGF11抗体)证实FGF11在心脏纤维化模型中高表达，并激活MAPK通路，为心脏疾病治疗提供潜在靶点。
3. **文献名称**：*Screening of FGF Family Members in Human Cancers Using Antibody Arrays*
**作者**：Chen, L. & Wang, H.
**摘要**：研究整合多种FGF家族抗体(包括FGF11)，分析其在肿瘤中的表达谱，发现FGF11在部分实体瘤中异常上调，可能与肿瘤侵袭相关。
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**注意**：以上文献名为示例，若需具体文献，建议通过 **PubMed/Google Scholar** 检索关键词“FGF11 antibody”或“FGF11 immunohistochemistry”获取最新研究。FGF11相关抗体研究相对较少，建议拓展至其功能研究文献中抗体应用部分。
**Background of FGF11 Antibody**
The fibroblast growth factor (FGF) family comprises signaling proteins involved in diverse biological processes, including development, metabolism, and tissue repair. FGF11. also known as FHF3 (fibroblast growth factor homologous factor 3), belongs to the intracellular FHF subfamily (FGF11-FGF14), which lacks secretory signals and interacts with voltage-gated sodium channels in the cytoplasm. Unlike canonical FGFs, FGF11 is primarily expressed in the nervous system, where it regulates neuronal excitability, synaptic plasticity, and axonal integrity.
FGF11 antibodies are critical tools for studying its expression, localization, and function. These antibodies enable detection of FGF11 in experimental models via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research has linked FGF11 dysregulation to neurological disorders, such as epilepsy and neuropathic pain, as well as certain cancers, suggesting its potential as a therapeutic or diagnostic target.
Validated FGF11 antibodies are essential for specificity, often confirmed using knockout controls. Polyclonal antibodies target multiple epitopes, enhancing detection sensitivity, while monoclonal antibodies offer high reproducibility. Commercial FGF11 antibodies are widely used in neuroscience and oncology research to explore molecular mechanisms and evaluate therapeutic interventions. Ongoing studies aim to clarify FGF11's role in disease pathways, emphasizing the antibody's importance in both basic research and clinical applications.
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