首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal NTT4 Antibody

  • 中文名： NTT4抗体
  • 别    名： SLC6A17; NTT4; Sodium-dependent neutral amino acid transporter SLC6A17; Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17
货号: IPDX23357
Price： ￥1180
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesSLC6A17; NTT4; Sodium-dependent neutral amino acid transporter SLC6A17; Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17
Entrez GeneID388662
WB Predicted band sizeCalculated MW: 81 kDa; Observed MW: 81 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from NTT4 . at AA range: 240-320
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

+ +

参考文献

以下是关于NTT4抗体的3篇示例文献(内容为虚构，仅供参考，实际文献需通过学术数据库检索)：

---

1. **文献名称**: *"Selective Monoclonal Antibody Generation for NTT4 Receptor: Validation in Neural Tissues"*

**作者**: Tanaka K, et al. (2018)

**摘要**: 本研究报道了一种针对NTT4受体胞外域的小鼠单克隆抗体的开发，通过免疫印迹和免疫组化验证其特异性。结果显示，该抗体可有效标记小鼠大脑海马区和皮质中的NTT4阳性神经元，为神经发育研究提供工具。

---

2. **文献名称**: *"NTT4 Antibody Reveals Differential Expression in Glioblastoma Multiforme"*

**作者**: Müller S, et al. (2020)

**摘要**: 利用商业化NTT4抗体(克隆号#AB-7C2)，研究者发现NTT4蛋白在胶质母细胞瘤组织中高表达，且与患者预后不良相关。抗体特异性通过siRNA敲减实验确认，支持其在癌症生物标志物研究中的应用。

---

3. **文献名称**: *"Cross-Species Reactivity of Anti-NTT4 Antibodies in Zebrafish Models"*

**作者**: Chen L, et al. (2021)

**摘要**: 本文评估了多种NTT4抗体的跨物种反应性，发现克隆#NT4-3A7在斑马鱼胚胎神经系统中具有高亲和力，证实NTT4在轴突导向中的作用，为比较进化研究提供技术支持。

---

如需真实文献，建议通过 **PubMed** 或 **Google Scholar** 检索关键词：

`NTT4 antibody immunohistochemistry`、`anti-NTT4 Western blot`、`NTT4 receptor characterization`。

背景信息

The NTT4 antibody targets the NTT4 protein, a member of the neurotrophin receptor tyrosine kinase (Trk) family, primarily associated with neural development and synaptic plasticity. Initially identified in studies exploring neurotrophin signaling pathways, NTT4 (also referred to as TrkB in some contexts) binds brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4), activating downstream cascades like MAPK, PI3K, and PLCγ to regulate neuronal survival, differentiation, and connectivity. Its expression is prominent in the central and peripheral nervous systems, particularly in regions critical for learning and memory, such as the hippocampus. Dysregulation of NTT4 signaling is implicated in neurodegenerative disorders (e.g., Alzheimer’s disease), psychiatric conditions (e.g., depression), and cancers (e.g., neuroblastoma). The NTT4 antibody, developed for research and diagnostic applications, enables detection of protein expression levels, phosphorylation status, and localization in tissues or cultured cells. It serves as a vital tool for elucidating NTT4’s role in pathological mechanisms and evaluating therapeutic interventions targeting neurotrophin pathways. Recent studies also explore its potential as a biomarker for neurological disease progression or treatment response.

客户数据及评论

折叠内容

大包装询价

×