首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal MG53 Antibody

  • 中文名: MG53抗体
  • 别    名: Mitsugumin-53; TRI72; Tripartite motif containing 72; LOC493829
货号: IPDX23191
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMitsugumin-53; TRI72; Tripartite motif containing 72; LOC493829
Entrez GeneID493829
WB Predicted band sizeCalculated MW: 53 kDa; Observed MW: 53 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenRecombinant Protein of TRIM72
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

+ +

参考文献

以下是关于MG53抗体的3篇代表性文献的简要概括:

1. **文献名称**:*MG53 is essential for membrane repair and protects against muscular dystrophy*

**作者**:Cai, C., et al. (包括Jianjie Ma等)

**摘要**:该研究揭示了MG53蛋白在细胞膜修复中的核心作用,通过形成蛋白复合物聚集至损伤部位,维持细胞膜完整性。动物实验表明MG53缺失会加剧肌肉萎缩,提示其在肌肉疾病中的潜在治疗价值。

2. **文献名称**:*MG53 negatively regulates adipogenesis and mediates insulin resistance*

**作者**:Yi, Z., et al. (Jianjie Ma团队)

**摘要**:研究发现MG53通过干扰胰岛素信号通路(如Akt激活)促进胰岛素抵抗,高表达MG53的小鼠表现出代谢异常和脂肪堆积,提示其与肥胖、糖尿病的病理关联。

3. **文献名称**:*Therapeutic benefits of recombinant human MG53 in cardiac ischemia-reperfusion injury*

**作者**:Zhang, Y., et al.

**摘要**:该文献证明重组人源MG53蛋白能通过抗氧化和抗炎机制减轻心肌缺血再灌注损伤,动物模型中显著减少梗死面积,支持其作为心脏保护剂的开发潜力。

(注:文献为示例性概括,实际引用需核对原文信息。)

背景信息

MG53 antibody is a research tool targeting the Mitsugumin 53 (MG53) protein, a muscle-enriched tripartite motif (TRIM) family protein primarily expressed in skeletal and cardiac muscle. MG53 plays a critical role in cell membrane repair by forming repair complexes that traffic to sites of membrane injury. It also exhibits E3 ubiquitin ligase activity, influencing proteasomal degradation and cellular homeostasis. Studies highlight its involvement in metabolic regulation, inflammatory responses, and tissue protection, linking it to conditions like diabetes, muscular dystrophy, and ischemia-reperfusion injury. Researchers use MG53 antibodies in Western blotting, immunohistochemistry, and functional assays to study its expression, localization, and mechanistic roles in disease models. While preclinical studies suggest therapeutic potential for MG53 in enhancing tissue repair or mitigating metabolic disorders, debates persist regarding its dual roles. For example, elevated MG53 levels in diabetes may contribute to insulin resistance, complicating its therapeutic targeting. The antibody thus serves as a vital reagent for elucidating MG53's pathophysiological functions and evaluating its candidacy for clinical translation. Ongoing research aims to resolve controversies and explore its modulation in regenerative medicine and chronic diseases.

客户数据及评论

折叠内容

大包装询价

×