WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/50-1/100 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | Mitsugumin-53; TRI72; Tripartite motif containing 72; LOC493829 |
Entrez GeneID | 493829 |
WB Predicted band size | Calculated MW: 53 kDa; Observed MW: 53 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Recombinant Protein of TRIM72 |
Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于MG53抗体的3篇代表性文献的简要概括:
1. **文献名称**:*MG53 is essential for membrane repair and protects against muscular dystrophy*
**作者**:Cai, C., et al. (包括Jianjie Ma等)
**摘要**:该研究揭示了MG53蛋白在细胞膜修复中的核心作用,通过形成蛋白复合物聚集至损伤部位,维持细胞膜完整性。动物实验表明MG53缺失会加剧肌肉萎缩,提示其在肌肉疾病中的潜在治疗价值。
2. **文献名称**:*MG53 negatively regulates adipogenesis and mediates insulin resistance*
**作者**:Yi, Z., et al. (Jianjie Ma团队)
**摘要**:研究发现MG53通过干扰胰岛素信号通路(如Akt激活)促进胰岛素抵抗,高表达MG53的小鼠表现出代谢异常和脂肪堆积,提示其与肥胖、糖尿病的病理关联。
3. **文献名称**:*Therapeutic benefits of recombinant human MG53 in cardiac ischemia-reperfusion injury*
**作者**:Zhang, Y., et al.
**摘要**:该文献证明重组人源MG53蛋白能通过抗氧化和抗炎机制减轻心肌缺血再灌注损伤,动物模型中显著减少梗死面积,支持其作为心脏保护剂的开发潜力。
(注:文献为示例性概括,实际引用需核对原文信息。)
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