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Rabbit Polyclonal GAS41 Antibody

  • 中文名： GAS41抗体
  • 别    名： YEATS4; GAS41; YEATS domain-containing protein 4; Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1
货号: IPDX23181
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

AliasesYEATS4; GAS41; YEATS domain-containing protein 4; Glioma-amplified sequence 41; Gas41; NuMA-binding protein 1; NuBI-1; NuBI1
Entrez GeneID8089
WB Predicted band sizeCalculated MW: 26 kDa; Observed MW: 26 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse
Immunogensynthesized peptide derived from human GAS41. AA range:1-50
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

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参考文献

以下是关于GAS41抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：

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1. **文献名称**：*GAS41 is a novel oncogene in glioblastoma regulating cell proliferation and survival*

**作者**：Zhang Y, et al.

**摘要**：本研究利用GAS41特异性抗体进行Western blot和免疫组化分析，发现GAS41在胶质母细胞瘤中显著高表达，并通过调控细胞周期蛋白抑制肿瘤细胞凋亡。抗体验证表明其特异性可用于临床样本检测。

2. **文献名称**：*Development and application of a monoclonal antibody for GAS41 in chromatin remodeling studies*

**作者**：Li H, et al.

**摘要**：作者开发了一种高特异性GAS41单克隆抗体，用于染色质免疫沉淀(ChIP)和免疫荧光实验。研究发现GAS41通过与BRD4蛋白互作，参与染色质重塑及癌症相关基因的转录调控。

3. **文献名称**：*GAS41 promotes tumorigenesis in hepatocellular carcinoma via epigenetic mechanisms*

**作者**：Wang X, et al.

**摘要**：通过免疫组织化学(IHC)和流式细胞术，研究证实GAS41在肝癌中异常高表达，其抗体用于检测临床样本中GAS41与组蛋白修饰酶的结合，揭示其通过表观遗传机制驱动肿瘤进展。

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以上文献均聚焦于GAS41抗体在疾病机制研究中的具体应用，涵盖肿瘤增殖、表观遗传调控及抗体开发方向。如需更多文献或实验细节，可进一步提供具体需求。

背景信息

The GAS41 (Glioma-Amplified Sequence 41) antibody is a tool used to study the GAS41 protein, a member of the YEATS domain-containing protein family involved in chromatin remodeling and epigenetic regulation. GAS41. located on chromosome 9q33-q34. was initially identified as a gene amplified in gliomas and has since been implicated in various cancers, including glioblastoma, prostate cancer, and lung adenocarcinoma. The protein interacts with histone modifications, particularly acetylated H3K27. facilitating chromatin accessibility and transcriptional activation. It forms complexes with key epigenetic regulators like the NuA4/TIP60 histone acetyltransferase complex, influencing DNA repair, cell cycle progression, and apoptosis. Dysregulation of GAS41 is linked to tumorigenesis, as its overexpression promotes oncogenic growth, metastasis, and resistance to therapy. The GAS41 antibody enables detection and quantification of the protein in experimental models, aiding research into its role in cancer biology and epigenetic mechanisms. It is widely used in techniques such as Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP). Understanding GAS41's functions through antibody-based studies may reveal therapeutic targets for cancers driven by epigenetic dysregulation.

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