| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-2B |
| Entrez GeneID | 84932 |
| WB Predicted band size | Calculated MW: 24 kDa; Observed MW: 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RAB2B. AA range:103-152 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Rab2B抗体的示例参考文献(内容为虚构，仅供格式参考)：
1. **文献名称**: "Rab2B regulates ER-Golgi trafficking and its antibody application in cancer cell imaging"
**作者**: Smith A, et al.
**摘要**: 研究利用Rab2B特异性抗体揭示其在内质网-高尔基体运输中的作用，并验证该抗体在乳腺癌细胞定位分析中的有效性。
2. **文献名称**: "Development of a monoclonal antibody against Rab2B for neurodegenerative disease research"
**作者**: Chen L, et al.
**摘要**: 报道一种高特异性Rab2B单克隆抗体的开发，证明其在阿尔茨海默病模型中对异常囊泡运输的检测潜力。
3. **文献名称**: "Rab2B antibody-based profiling reveals its role in autophagosome-lysosome fusion"
**作者**: Tanaka K, et al.
**摘要**: 通过Rab2B抗体免疫沉淀技术，发现Rab2B参与自噬体-溶酶体膜融合过程，为自噬调控机制提供新证据。
4. **文献名称**: "Rab2B as a biomarker in pancreatic cancer: validation via immunohistochemistry"
**作者**: Rodriguez M, et al.
**摘要**: 使用商业化Rab2B抗体进行胰腺癌组织染色，证实其表达水平与肿瘤转移和预后相关。
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**备注**：以上文献为示例，实际文献请通过 **PubMed/Google Scholar** 检索关键词 "Rab2B antibody" 或相关研究领域获取。
Rab2B, a member of the Rab GTPase family, plays a critical role in regulating intracellular membrane trafficking pathways. Belonging to the Ras superfamily, Rab proteins are essential for vesicle formation, transport, and fusion, ensuring precise cargo delivery between organelles. Rab2B is closely related to Rab2A, sharing structural homology but differing in tissue distribution and functional specificity. It is primarily localized to the Golgi apparatus and endoplasmic reticulum (ER), where it facilitates anterograde and retrograde transport of vesicles, particularly in the early secretory pathway. Studies suggest Rab2B involvement in maintaining Golgi structure, ER-Golgi intermediate compartment (ERGIC) dynamics, and autophagosome-lysosome fusion.
Rab2B-specific antibodies are vital tools for investigating its expression, localization, and interactions in cellular processes. These antibodies enable detection via techniques like immunofluorescence, Western blotting, and immunoprecipitation, aiding in the study of Rab2B's role in physiological and pathological contexts. Dysregulation of Rab2B has been implicated in neurodegenerative diseases, cancer progression, and metabolic disorders, highlighting its potential as a therapeutic target. For instance, aberrant Rab2B expression correlates with tumor invasiveness and poor prognosis in certain cancers. Researchers also utilize these antibodies to explore Rab2B's interplay with other trafficking regulators, such as COPI/COPII coat proteins and SNARE complexes. Despite progress, Rab2B's full mechanistic spectrum remains under investigation, necessitating continued development of high-specificity antibodies for functional and clinical studies.
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