| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 1/50-1/100 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II subunit beta; CaMK-II subunit beta; CAMK2G; CAMK; CAMK-II; CAMKG; Calcium/calmodulin-dependent protein kinase type II subunit gamma |
| Entrez GeneID | 816 |
| WB Predicted band size | Calculated MW: 73 kDa; Observed MW: 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human CaMKII |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CaMKIIβ抗体的3篇参考文献(示例性内容，实际文献需根据具体数据库检索)：
1. **文献名称**：*"Characterization of CaMKIIβ antibody specificity in neuronal development"*
**作者**：Smith A, et al.
**摘要**：该研究验证了一种新型CaMKIIβ抗体的特异性，通过Western blot和免疫组化证明其在区分CaMKIIβ与其他CaMKII亚型(如α)中的高效性，并应用于小鼠脑发育模型中观察蛋白表达动态。
2. **文献名称**：*"Role of CaMKIIβ in synaptic plasticity: Insights from antibody-based localization studies"*
**作者**：Jones R, et al.
**摘要**：利用CaMKIIβ特异性抗体进行免疫荧光染色，揭示其在海马神经元突触后密集区的富集，并通过敲除实验证实其与长时程增强(LTP)调控的关联。
3. **文献名称**：*"Development and validation of a monoclonal CaMKIIβ antibody for human tissue analysis"*
**作者**：Lee H, et al.
**摘要**：研究报道了一种人源特异性CaMKIIβ单克隆抗体的开发，通过ELISA、流式细胞术和病理组织染色验证其可靠性，并应用于阿尔茨海默病模型中检测蛋白异常聚集。
(注：以上文献为模拟示例，实际引用需查询PubMed、Web of Science等数据库获取真实文献。)
The CaMKII beta antibody is a crucial tool in neuroscience and molecular biology research, targeting the beta isoform of calcium/calmodulin-dependent protein kinase II (CaMKII), a multifunctional serine/threonine kinase. CaMKII is central to calcium signaling pathways, particularly in the brain, where it regulates synaptic plasticity, learning, and memory. While the alpha isoform (CaMKIIα) is predominantly neuronal, CaMKIIβ is expressed in both neuronal and non-neuronal tissues, with roles in cytoskeletal dynamics, cell cycle regulation, and dendritic spine morphogenesis. The beta isoform uniquely interacts with F-actin, linking calcium signaling to structural remodeling in neurons.
CaMKIIβ antibodies enable detection, localization, and functional analysis of the protein in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. They are essential for studying CaMKIIβ’s dual roles in kinase-dependent signaling and kinase-independent structural scaffolding. Researchers use these antibodies to explore its involvement in neurodevelopmental disorders, neurodegenerative diseases (e.g., Alzheimer’s), and cancer, where aberrant CaMKIIβ expression or activity may contribute to pathogenesis. Specificity validation (e.g., knockout controls) is critical due to high homology among CaMKII isoforms. Such antibodies have advanced understanding of calcium-mediated cellular adaptation and disease mechanisms.
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