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Rabbit Polyclonal ParathyroidHormone Antibody

  • 中文名： Parathyroid Hormone抗体
  • 别    名： hPTH; Parathormone; Parathyrin; Parathyroid hormone 1; Prepro PTH; Preproparathyroid hormone; PTH1; PTH1 receptor; PTH1R; PTHR1
货号: IPDX22948
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliaseshPTH; Parathormone; Parathyrin; Parathyroid hormone 1; Prepro PTH; Preproparathyroid hormone; PTH1; PTH1 receptor; PTH1R; PTHR1
Entrez GeneID5741
WB Predicted band sizeCalculated MW: 13 kDa; Observed MW: 36 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenA synthesized peptide derived from human Parathyroid Hormone
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于甲状旁腺激素(Parathyroid Hormone, PTH)抗体的参考文献示例(注：文献为虚构示例，仅作格式参考，实际文献需通过学术数据库查询)：

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1. **标题**: *Development of a Monoclonal Antibody-Based ELISA for Human Parathyroid Hormone*

**作者**: Smith J, et al.

**摘要**: 该研究描述了针对人PTH C端表位的单克隆抗体的开发，并建立了一种高灵敏度的ELISA检测方法，用于血清中完整PTH分子的定量分析，为甲状旁腺功能异常的临床诊断提供了工具。

2. **标题**: *Characterization of PTH Antibodies in Immunoassays: Impact on Clinical Results*

**作者**: Lee H, et al.

**摘要**: 分析了不同PTH抗体(针对N端与C端表位)在免疫检测中的交叉反应性，发现抗体选择显著影响检测结果准确性，尤其对继发性甲状旁腺功能亢进患者的诊断具有临床意义。

3. **标题**: *Novel Biphasic PTH Assay Using Dual-Antibody Recognition for Improved Specificity*

**作者**: Garcia R, et al.

**摘要**: 提出一种基于双抗体夹心法的检测技术，结合针对PTH(1-84)和PTH(7-84)的两种抗体，有效区分完整PTH与降解片段，减少慢性肾病患者的误诊率。

4. **标题**: *Cross-Reactivity of Parathyroid Hormone Antibodies with Other Peptide Hormones: A Comparative Study*

**作者**: Tanaka K, et al.

**摘要**: 通过质谱验证，揭示了某些商品化PTH抗体可能与PTHrP(甲状旁腺激素相关蛋白)发生交叉反应，提示临床检测中需谨慎选择高特异性抗体以避免假阳性结果。

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建议通过PubMed或Google Scholar搜索以下关键词获取真实文献：

`Parathyroid Hormone antibody`, `PTH immunoassay`, `monoclonal antibody PTH`, `PTH assay specificity`.

背景信息

Parathyroid hormone (PTH) antibodies are specialized immunoglobulins designed to detect or neutralize PTH, a critical peptide hormone produced by the parathyroid glands. PTH regulates calcium and phosphate homeostasis by acting on bones, kidneys, and the gastrointestinal tract. Its dysregulation is linked to disorders like hyperparathyroidism, hypoparathyroidism, and chronic kidney disease. PTH antibodies serve as essential tools in both research and clinical diagnostics. In immunoassays (e.g., ELISA, immunoradiometric assays), these antibodies enable quantitative measurement of PTH levels in serum, aiding in disease diagnosis and monitoring. Polyclonal antibodies, which recognize multiple epitopes, offer high sensitivity but may cross-react with PTH fragments. Monoclonal antibodies, targeting specific epitopes, provide higher specificity, particularly in distinguishing full-length active PTH (1-84) from inactive fragments (e.g., 7-84), improving diagnostic accuracy. Challenges persist in ensuring antibody specificity due to structural similarities between PTH and related peptides or cleavage products. Additionally, PTH antibodies are utilized in immunohistochemistry to study parathyroid gland pathology or ectopic PTH production in tumors. Emerging therapeutic applications include neutralizing antibodies for managing PTH excess in secondary hyperparathyroidism. Validation of these antibodies requires rigorous testing against isoforms and matrix effects to avoid assay interference. Their development continues to advance precision medicine in metabolic bone diseases.

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