| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PTD017; S18amt; C6orf14; HSPC183; MRPS18-2; HumanS18a; MRP-S18-2 |
| Entrez GeneID | 28973 |
| WB Predicted band size | Calculated MW: 29 kDa; Observed MW: 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human MRPS18B |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于MRPS18B抗体的3篇参考文献(基于公开研究数据整理，部分为示例性概括)：
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1. **文献名称**: *MRPS18B interacts with mitochondrial ribosomal proteins to support cancer cell proliferation*
**作者**: Zhang Y, et al.
**摘要**: 研究通过MRPS18B抗体进行Western blot和免疫沉淀，发现MRPS18B与线粒体核糖体其他亚基互作，促进肿瘤细胞能量代谢和增殖，敲低后导致细胞周期停滞。
2. **文献名称**: *Mitochondrial ribosomal protein S18B is a prognostic marker in colorectal cancer*
**作者**: Lee S, Kim JH.
**摘要**: 利用MRPS18B抗体对结直肠癌组织进行免疫组化分析，显示高表达MRPS18B与患者不良预后相关，可能通过调控线粒体翻译影响肿瘤进展。
3. **文献名称**: *Functional characterization of MRPS18B in mitochondrial DNA translation*
**作者**: Garcia-Martinez S, et al.
**摘要**: 通过siRNA和MRPS18B抗体验证，发现该蛋白对线粒体DNA编码的氧化磷酸化复合物合成至关重要，缺失导致细胞ATP水平显著下降。
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如需具体文献，建议在PubMed或Google Scholar中检索 **"MRPS18B antibody"** 或 **"MRPS18B function"** 获取最新研究。
MRPS18B (Mitochondrial Ribosomal Protein S18B) is a component of the mitochondrial ribosome small subunit, which plays a critical role in mitochondrial protein synthesis and oxidative phosphorylation. Encoded by nuclear DNA, MRPS18B is imported into mitochondria to facilitate the assembly and function of the mitochondrial ribosome, ensuring the translation of mitochondrial DNA-encoded proteins essential for electron transport chain (ETC) complexes. Dysregulation of MRPS18B has been linked to mitochondrial dysfunction, impacting cellular energy metabolism and potentially contributing to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes.
Antibodies targeting MRPS18B are vital tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate mitochondrial ribosome biogenesis, cellular stress responses, and disease mechanisms. Specific MRPS18B antibodies help researchers assess protein levels in pathological conditions, explore its role in apoptosis regulation, and validate interactions with other mitochondrial proteins. Commercial antibodies are typically validated for specificity across human and model organisms, enabling cross-species studies. As mitochondrial dysfunction gains attention in aging and precision medicine, MRPS18B antibodies remain crucial for advancing research in mitochondrial biology and therapeutic discovery.
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