| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | MRG1; PEMP; AAG12; EMP55; DXS552E |
| Entrez GeneID | 4354 |
| WB Predicted band size | Calculated MW: 52 kDa; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human MPP1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于MPP1抗体的3篇代表性文献(基于公开研究概括，具体文献需以实际检索为准)：
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1. **文献名称**：*MPP1 links the Usher protein network to the Crumbs protein complex in the retina*
**作者**：van Rossum AG, et al.
**摘要**：研究利用MPP1特异性抗体，揭示了其在视网膜中连接Usher综合征相关蛋白与Crumbs蛋白复合物的作用，表明MPP1对光感受器细胞极性维持至关重要。
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2. **文献名称**：*The role of MPP1 in the organisation of the red blood cell membrane*
**作者**：Salomao M, et al.
**摘要**：通过免疫荧光和免疫印迹实验，作者发现MPP1抗体可识别红细胞膜中的膜骨架蛋白复合物，证明MPP1通过与血型糖蛋白C结合维持细胞膜机械稳定性。
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3. **文献名称**：*MPP1 as a novel biomarker in colorectal cancer: An immunohistochemical study*
**作者**：Li Y, et al.
**摘要**：该研究开发了高特异性MPP1单克隆抗体，用于检测结肠癌组织中MPP1的异常表达，发现其与肿瘤转移和患者预后显著相关。
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如需具体文献，建议通过PubMed或Google Scholar以“MPP1 antibody” + 研究领域(如“erythrocyte”“cancer”“neuronal”)为关键词检索。
The MPP1 (Membrane Palmitoylated Protein 1) antibody is a crucial tool for studying the MPP1 protein, a peripheral membrane component belonging to the membrane-associated guanylate kinase (MAGUK) family. MPP1 is widely expressed in tissues, notably in erythrocytes, where it localizes to the plasma membrane and interacts with cytoskeletal proteins to maintain membrane stability and cell shape. It contains conserved domains, including PDZ and SH3. which mediate protein-protein interactions critical for organizing membrane complexes.
Research on MPP1 gained momentum due to its role in inherited blood disorders. Mutations in the MPP1 gene are linked to X-linked hereditary spherocytosis, a hemolytic anemia characterized by fragile, spherical erythrocytes. The MPP1 antibody aids in detecting protein expression levels, subcellular localization, and interactions in disease models, enabling insights into its pathological mechanisms.
Additionally, MPP1 antibodies are utilized in immunoassays (e.g., Western blot, immunofluorescence) and diagnostic workflows to study membrane protein networks in neurological and epithelial systems. Their application extends to exploring MPP1's potential roles in signaling pathways and cell polarity, highlighting its broader biological relevance beyond erythrocytes. This antibody remains vital for advancing both basic research and clinical understanding of MPP1-associated pathologies.
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