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| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1QTNF1 |
| Uniprot No | Q9BXJ1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 26-281aa |
| 氨基酸序列 | RVPHVQGEQQEWEGTEELPSPPDHAERAEEQHEKYRPSQDQGLPASRCLR CCDPGTSMYP ATAVPQINITILKGEKGDRGDRGLQGKYGKTGSAGARGHTGPKGQKGSMG APGERCKSHY AAFSVGRKKPMHSNHYYQTVIFDTEFVNLYDHFNMFTGKFYCYVPGLYFF SLNVHTWNQK ETYLHIMKNEEEVVILFAQVGDRSIMQSQSLMLELREQDQVWVRLYKGER ENAIFSEELD TYITFSGYLVKHATEP |
| 预测分子量 | 29 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于C1QTNF1重组蛋白的3篇参考文献及其摘要概括：
1. **文献名称**: "C1q/TNF-related protein 1 (CTRP1) modulates adipogenesis and mitochondrial biogenesis in 3T3-L1 adipocytes"
**作者**: Wei, Z., Peterson, J. M., Wong, G. W.
**摘要**: 研究利用重组CTRP1蛋白处理3T3-L1脂肪细胞，发现其通过激活AMPK信号通路促进脂肪细胞分化和线粒体生物合成，提示其在调节能量代谢中的作用。
2. **文献名称**: "Recombinant C1q/TNF-related protein 1 (CTRP1) suppresses tumor necrosis factor-α-induced inflammatory responses in endothelial cells"
**作者**: Akiyama, H., Yamaguchi, H., Shimizu, E. et al.
**摘要**: 该研究证明重组CTRP1蛋白可抑制TNF-α诱导的内皮细胞炎症反应，通过阻断NF-κB通路减少黏附分子表达，表明其在动脉粥样硬化中的潜在治疗价值。
3. **文献名称**: "Structural and functional characterization of recombinant human C1qTNF1 protein"
**作者**: Li, Y., Zhang, L., Chen, J.
**摘要**: 通过大肠杆菌表达系统制备重组人C1QTNF1蛋白，解析其晶体结构并验证其与补体C1q受体的结合能力，为后续功能研究提供结构基础。
注：若需实际引用，建议通过PubMed或Web of Science核对文献详细信息及原文内容。
C1QTNF1 (C1q and tumor necrosis factor-related protein 1), also known as CTRP1. is a member of the C1q/TNF-related protein (CTRP) family, which shares structural homology with adiponectin and TNF-α. This secreted glycoprotein is composed of four distinct domains: a signal peptide, a short variable region, a collagen-like domain, and a C-terminal globular C1q domain. It plays multifunctional roles in metabolic regulation, inflammation, and tissue remodeling. C1QTNF1 is expressed in various tissues, including adipose tissue, skeletal muscle, and the cardiovascular system, where it interacts with cell surface receptors to modulate signaling pathways such as AMPK, Akt, and NF-κB.
Recombinant C1QTNF1 protein is engineered using expression systems like mammalian cells or *E. coli* to produce purified, biologically active forms for research and therapeutic exploration. Its recombinant form enables studies on its role in glucose metabolism, lipid homeostasis, and insulin sensitivity, with implications for metabolic disorders like obesity and diabetes. Additionally, C1QTNF1 exhibits anti-inflammatory properties and promotes angiogenesis, making it a potential target for cardiovascular diseases and tissue repair. Recent studies also suggest its involvement in bone formation and cancer progression, highlighting its broad regulatory functions. The development of recombinant C1QTNF1 has accelerated mechanistic studies and preclinical evaluations, offering insights into its therapeutic potential for metabolic and inflammatory diseases. However, its dual roles in different pathological contexts require further investigation to fully understand its clinical applicability.
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