首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal SF3A3 Antibody

  • 中文名： SF3A3抗体
  • 别    名： splicing factor 3a subunit 3; PRP9; PRPF9; SAP61; SF3a60
货号: IPDX22202
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat,Hamster
IF 咨询技术 Human,Mouse,Rat,Hamster
IHC 咨询技术 Human,Mouse,Rat,Hamster
ICC 技术咨询 Human,Mouse,Rat,Hamster
FCM 咨询技术 Human,Mouse,Rat,Hamster
Elisa 咨询技术 Human,Mouse,Rat,Hamster

产品详情

Aliasessplicing factor 3a subunit 3; PRP9; PRPF9; SAP61; SF3a60
Entrez GeneID10946
WB Predicted band sizeCalculated MW: 59 kDa; Observed MW: 59 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat,Hamster
ImmunogenA synthetic peptide of human SF3A3
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是关于SF3A3抗体的3篇参考文献示例(文献信息为模拟概括，非真实存在)：

1. **文献名称**：*SF3A3 modulates spliceosome assembly in human cells*

**作者**：Zhang L, et al.

**摘要**：研究通过SF3A3抗体进行免疫沉淀和质谱分析，揭示SF3A3在剪接体早期组装中的关键作用及其与其他核心蛋白的相互作用。

2. **文献名称**：*Dysregulation of SF3A3 in colorectal cancer progression*

**作者**：Wang Y, et al.

**摘要**：利用SF3A3抗体进行免疫组化分析，发现SF3A3在结直肠癌组织中高表达，并与患者预后不良相关，提示其作为潜在肿瘤标志物。

3. **文献名称**：*Antibody-based profiling of spliceosome components in neurodegenerative diseases*

**作者**：Smith J, et al.

**摘要**：通过Western blot和免疫荧光技术，验证SF3A3抗体特异性，并发现阿尔茨海默病患者脑组织中SF3A3表达水平异常，可能与RNA剪接缺陷相关。

注：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台以“SF3A3 antibody”为关键词检索获取。

背景信息

The SF3A3 antibody targets the splicing factor 3A subunit 3 (SF3A3), a critical component of the U2 small nuclear ribonucleoprotein (snRNP) complex within the spliceosome. SF3A3. along with SF3A1 and SF3A2. forms the SF3a subcomplex, essential for pre-mRNA splicing. It facilitates spliceosome assembly by stabilizing interactions between U2 snRNA and the branch site of introns during the early stages of splicing. SF3A3 antibodies are widely used to study spliceosome dynamics, RNA processing mechanisms, and their dysregulation in diseases like cancer. Mutations in spliceosome components, including SF3A3. are linked to hematologic malignancies and solid tumors. These antibodies are valuable tools in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interactions. Additionally, they aid in exploring therapeutic strategies targeting spliceosome alterations, such as small molecule inhibitors modulating SF3a/b complexes. Research using SF3A3 antibodies has advanced understanding of splicing fidelity, alternative splicing regulation, and their roles in cellular homeostasis or disease pathogenesis. The antibody's specificity for the ~60 kDa SF3A3 protein ensures precise detection in model organisms and human tissues.

客户数据及评论

折叠内容

大包装询价

×