| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | mitochondrial; selenoprotein Z; SELZ; Thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR 3; TR; TR beta; TR-beta; TRXR 2; TRXR2; TRXR2_HUMAN; TXNRD 2; Txnrd2. |
| Entrez GeneID | 10587 |
| WB Predicted band size | Calculated MW: 57 kDa; Observed MW: 57 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human TXNRD2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Thioredoxin Reductase 2(TrxR2)抗体的参考文献及其摘要概括：
1. **"Mitochondrial thioredoxin reductase 2 is essential for embryonic development and cell proliferation"**
*作者：Conrad M, et al.*
**摘要**：本研究利用基因敲除小鼠模型，通过TrxR2特异性抗体检测发现，TrxR2缺失导致胚胎致死及细胞增殖障碍，证明其在线粒体氧化还原稳态中的关键作用。
2. **"Thioredoxin reductase 2 deficiency alters murine cardiac mitochondrial lipid metabolism and sensitizes to ischemia-reperfusion injury"**
*作者：Zhang H, et al.*
**摘要**：通过Western blot和免疫组化(使用TrxR2抗体)分析发现，TrxR2缺陷小鼠心脏线粒体脂代谢异常，并加剧缺血再灌注损伤，提示TrxR2在心脏保护中的功能。
3. **"Selective targeting of thioredoxin reductase 2 by organogold compounds for cancer therapy"**
*作者：Peng X, et al.*
**摘要**：研究利用TrxR2抗体验证癌细胞中TrxR2的过表达，并开发靶向TrxR2的金基化合物，通过抑制其活性诱导癌细胞凋亡，为癌症治疗提供新策略。
(注：以上文献标题及内容为示例性概括，实际引用需以真实发表文献为准。)
Thioredoxin Reductase 2 (TrxR2) is a mitochondrial enzyme critical for maintaining cellular redox homeostasis. As a key component of the thioredoxin (Trx) system, it catalyzes the reduction of oxidized thioredoxin 2 (Trx2) using NADPH, thereby regulating mitochondrial antioxidant defense, redox signaling, and apoptosis. TrxR2 is encoded by the TXNRD2 gene and is essential for embryonic development, as its knockout in mice leads to embryonic lethality due to severe oxidative stress.
Antibodies targeting TrxR2 are widely used to study its expression, localization, and function in physiological and pathological contexts. These antibodies enable detection of TrxR2 in techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping researchers investigate its role in diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. Dysregulation of TrxR2 has been linked to mitochondrial dysfunction, altered cell proliferation, and resistance to chemotherapy, making it a potential therapeutic target.
Commercial TrxR2 antibodies are typically validated for specificity against human, mouse, or rat isoforms, with some distinguishing between cytosolic (TrxR1) and mitochondrial (TrxR2) forms. Proper validation, including knockout controls, is crucial due to structural similarities within the thioredoxin reductase family. These tools are indispensable for exploring mitochondrial redox biology and its implications in health and disease.
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