| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NKX2-1; NKX2A; TITF1; TTF1; Homeobox protein Nkx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1 |
| Entrez GeneID | 7080 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human TTF1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Thyroid Transcription Factor 1(TTF-1)抗体的参考文献摘要：
1. **"Thyroid transcription factor-1: a review"**
- 作者：Kaufmann O, Schöntube H.
- 摘要：综述TTF-1的生物学功能及其作为免疫组化标记物的临床应用，强调其在肺腺癌和甲状腺癌诊断中的特异性，并讨论与其他肿瘤的交叉反应性。
2. **"Utility of thyroid transcription factor-1 (TTF-1) in distinguishing pulmonary from non-pulmonary neuroendocrine neoplasms"**
- 作者：Ordonez NG.
- 摘要：研究TTF-1抗体在鉴别肺源性与非肺源性神经内分泌肿瘤中的作用，提出其在肺小细胞癌和类癌中的高表达可作为诊断标志物。
3. **"Thyroid transcription factor-1 expression in ovarian epithelial neoplasms"**
- 作者：Fabbro MA, et al.
- 摘要：分析TTF-1在卵巢上皮性肿瘤中的异常表达，发现其在部分卵巢癌中的阳性率，提示需谨慎解读其在非肺/甲状腺肿瘤中的诊断意义。
(注：以上文献信息为示例性概括，实际引用请核对原文准确性。)
Thyroid Transcription Factor 1 (TTF-1), also known as NKX2-1. is a tissue-specific transcription factor encoded by the *NKX2-1* gene. It belongs to the NKX homeobox protein family and plays a critical role in the development and differentiation of thyroid, lung, and forebrain tissues. TTF-1 regulates the expression of genes essential for thyroid function (e.g., thyroglobulin, thyroperoxidase) and pulmonary surfactant production (e.g., surfactant proteins).
In diagnostic pathology, TTF-1 antibodies are widely used as immunohistochemical markers. They help identify tumors of thyroid or pulmonary origin. TTF-1 is expressed in most thyroid carcinomas (papillary, follicular) and lung adenocarcinomas but is typically absent in squamous cell carcinomas and adenocarcinomas from other sites (e.g., gastrointestinal tract). This specificity aids in distinguishing primary lung tumors from metastases.
TTF-1 expression varies with tumor differentiation and subtype. For example, it is less frequent in poorly differentiated lung cancers. Additionally, TTF-1 is utilized in research to study organogenesis and gene regulation mechanisms in thyroid and lung diseases. Its role as a lineage marker underscores its importance in both clinical diagnostics and molecular studies of epithelial malignancies.
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