| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-45 |
| Entrez GeneID | 158158 |
| WB Predicted band size | Calculated MW: 83 kDa; Observed MW: 83 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human RAB45 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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关于Rab45抗体的研究目前较为有限，以下为模拟的参考文献示例(请注意这些文献为虚构，实际需通过学术数据库验证)：
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1. **标题**: *Rab45 in Vesicular Trafficking: A Novel Role in Golgi-ER Communication*
**作者**: Zhang L, et al.
**摘要**: 本研究首次报道Rab45在调节高尔基体与内质网之间的囊泡运输中的作用，通过特异性抗体证实其在细胞器膜上的定位，并揭示其与SNARE蛋白的相互作用。
2. **标题**: *Development and Validation of a Polyclonal Antibody Against Human Rab45*
**作者**: Kim S, et al.
**摘要**: 文章描述了一种针对人源Rab45蛋白的多克隆抗体的开发，验证了其在免疫印迹和免疫荧光中的特异性，并用于检测Rab45在癌细胞中的异常表达。
3. **标题**: *Rab45 Dysregulation in Neurodegenerative Diseases: Insights from Mouse Models*
**作者**: Müller R, et al.
**摘要**: 利用Rab45抗体研究小鼠脑组织，发现Rab45在神经元中的表达异常与突触蛋白运输缺陷相关，提示其可能在阿尔茨海默病中起病理作用。
4. **标题**: *Rab45 Interaction with the Cytoskeleton: Implications for Cell Migration*
**作者**: Patel A, et al.
**摘要**: 通过免疫共沉淀和抗体阻断实验，证明Rab45与肌动蛋白骨架的动态调控相关，影响肿瘤细胞的迁移和侵袭能力。
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**注意**：以上文献为示例，实际研究中Rab45可能并非标准命名。建议通过 **PubMed** 或 **Google Scholar** 使用关键词“Rab45 antibody”或“Rab45 GTPase”检索真实文献。若结果不足，可核查目标蛋白的命名准确性(如是否为Rab4A、Rab5C等同源物)。
**Background of Rab45 Antibody**
Rab45 is a member of the Rab GTPase family, which plays critical roles in regulating intracellular membrane trafficking, vesicle transport, and organelle dynamics. Unlike many canonical Rabs associated with secretory or endocytic pathways, Rab45 has unique structural and functional characteristics. It contains a conserved GTP-binding domain but features an extended C-terminal region, suggesting potential roles in specialized cellular processes. Rab45 is implicated in calcium-dependent exocytosis, membrane repair, and cytoskeletal reorganization, linking it to processes like cell migration, secretion, and possibly autophagy.
Studies indicate that Rab45 is expressed in specific tissues, including the brain, testis, and immune cells, hinting at tissue-specific regulatory functions. Its involvement in neuronal exocytosis and synaptic vesicle release has drawn interest in neurological disorders. Additionally, Rab45 may interact with proteins involved in membrane fusion (e.g., SNAREs) and calcium sensors, highlighting its regulatory complexity.
Rab45 antibodies are essential tools for detecting Rab45 expression, localization, and interactions in research. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding investigations into its physiological and pathological roles. Dysregulation of Rab45 has been tentatively associated with cancer metastasis and neurodegenerative conditions, though its mechanisms remain understudied. Validated Rab45 antibodies are crucial for elucidating its contributions to cellular homeostasis and disease, making them valuable in both basic and translational research contexts.
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