| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-22A |
| Entrez GeneID | 57403 |
| WB Predicted band size | Calculated MW: 22 kDa; Observed MW: 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human RAB22A |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于Rab22A抗体的3篇参考文献概览：
1. **文献名称**: "Rab22A regulates the recycling of membrane-type EGFR to promote tumor metastasis"
**作者**: Wang T, et al.
**摘要**: 该研究利用Rab22A特异性抗体，发现Rab22A通过调控EGFR的循环途径促进肿瘤细胞的侵袭与转移，为靶向治疗提供潜在靶点。
2. **文献名称**: "Rab22A is required for influenza A virus infection via endocytic trafficking"
**作者**: Li Y, et al.
**摘要**: 通过抗体阻断实验，证明Rab22A在甲型流感病毒内吞过程中起关键作用，抑制其活性可显著降低病毒感染效率。
3. **文献名称**: "Rab22A promotes autophagy and chemoresistance in ovarian cancer via mTOR signaling"
**作者**: Chen X, et al.
**摘要**: 研究采用Rab22A抗体揭示其在卵巢癌自噬激活和化疗耐药中的作用机制，靶向Rab22A可逆转顺铂耐药性。
*注：以上文献信息为模拟示例，实际引用请核对真实论文数据。*
Rab22A antibody is a crucial tool for studying the Rab22A protein, a member of the Rab GTPase family involved in regulating intracellular vesicular trafficking. Rab GTPases act as molecular switches, cycling between active (GTP-bound) and inactive (GDP-bound) states to control membrane dynamics, cargo sorting, and vesicle transport. Rab22A localizes to early endosomes and recycling compartments, where it influences endocytic sorting, receptor recycling, and endosome-cytoskeleton interactions. Emerging research highlights its role in cancer progression, particularly in promoting tumor invasion, metastasis, and drug resistance by modulating pathways like epithelial-mesenchymal transition (EMT) and hypoxia responses. Dysregulation of Rab22A is linked to poor prognosis in multiple cancers, including breast, liver, and ovarian cancer.
Rab22A antibodies enable the detection and functional analysis of Rab22A expression and localization in cells or tissues. They are widely used in techniques such as Western blotting, immunofluorescence, and immunohistochemistry to investigate its role in cellular processes or disease mechanisms. Specificity and validation are critical, as cross-reactivity with other Rab family members can compromise data accuracy. Recent studies also explore Rab22A’s interaction with oncogenic proteins, making its antibody a valuable resource for therapeutic target discovery. By elucidating Rab22A’s regulatory networks, these antibodies contribute to understanding trafficking-related pathologies and developing precision oncology strategies.
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