| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | RAB10 |
| Entrez GeneID | 10890 |
| WB Predicted band size | Calculated MW: 23 kDa; Observed MW: 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Recombinant protein of human RAB10 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
+ +
以下是3篇与Rab10抗体相关的文献摘要示例(人工概括，非真实文献)：
1. **"Rab10 regulates vesicular transport in neuronal axons"**
*Author: Mori Y, et al.*
摘要：研究使用特异性Rab10抗体揭示其在神经元轴突内吞运输中的作用，证明Rab10缺失导致突触囊泡循环障碍。
2. **"Rab10 phosphorylation in Alzheimer's disease models"**
*Author: Chen S, et al.*
摘要：通过Rab10抗体检测阿尔茨海默病小鼠模型中Rab10的磷酸化水平变化，发现其与β-淀粉样蛋白异常转运相关。
3. **"Rab10 antibody validation in Drosophila epithelial polarization"**
*Author: Kiral FR, et al.*
摘要：开发高特异性Rab10抗体并应用于果蝇模型，证实Rab10通过调控基底膜蛋白运输维持上皮细胞极性。
4. **"Rab10-mediated autophagy in metabolic disorders"**
*Author: Li X, et al.*
摘要：利用Rab10抗体进行免疫荧光分析，揭示Rab10通过调控自噬小体-溶酶体融合影响胰岛素敏感性。
注：以上为模拟摘要，实际文献需通过PubMed/Google Scholar检索确认。
Rab10 is a member of the Rab GTPase family, which regulates intracellular vesicular trafficking and membrane dynamics. It plays a critical role in exocytosis, endocytosis, and organelle biogenesis by cycling between active (GTP-bound) and inactive (GDP-bound) states. Rab10 is particularly implicated in the trafficking of secretory vesicles, autophagosomes, and recycling endosomes. Studies highlight its involvement in neuronal development, lipid metabolism, and cellular signaling pathways. Dysregulation of Rab10 has been linked to neurological disorders (e.g., Alzheimer’s disease, Parkinson’s disease), metabolic conditions (e.g., diabetes, obesity), and cancer progression.
Rab10 antibodies are essential tools for detecting Rab10 expression, localization, and function in various experimental settings. Commonly used in techniques like Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP), these antibodies target specific epitopes or isoforms of Rab10. Commercial antibodies, such as clone C4B2. are validated for specificity across human, mouse, and rat samples. Suppliers like Cell Signaling Technology, Abcam, and Sigma-Aldrich offer Rab10 antibodies, often accompanied by knockout-validated data. Researchers utilize these antibodies to explore Rab10’s role in membrane trafficking mechanisms, disease pathology, and potential therapeutic targets, making them indispensable in cell biology and biomedical research.
×
