| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | IEF-SSP-9502 |
| Entrez GeneID | 11137 |
| WB Predicted band size | Calculated MW: 56 kDa; Observed MW: 75 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | A synthetic peptide of human PWP1 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于PWP1抗体的示例参考文献(注：以下为模拟示例，具体文献需通过学术数据库验证)：
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1. **文献名称**: *PWP1 mediates ribosome assembly in Saccharomyces cerevisiae*
**作者**: Müller, S. et al.
**摘要**: 研究报道了酵母PWP1蛋白在核糖体大亚基成熟中的作用，通过Western blot和免疫荧光技术验证了PWP1抗体的特异性，并发现PWP1缺失导致核糖体组装缺陷。
2. **文献名称**: *Human PWP1 regulates cell cycle progression via rRNA processing*
**作者**: Chen, L. & Wang, X.
**摘要**: 利用PWP1抗体进行免疫沉淀和RNA干扰实验，发现人类PWP1通过调控rRNA加工影响细胞周期进程，其表达异常与癌症增殖相关。
3. **文献名称**: *Development of a monoclonal antibody against PWP1 for diagnostic applications*
**作者**: Kim, J. et al.
**摘要**: 描述了新型PWP1单克隆抗体的开发与验证，证实其在ELISA和免疫组化中的高特异性，为疾病生物标志物研究提供了工具。
4. **文献名称**: *PWP1 interacts with chromatin modifiers in stem cell differentiation*
**作者**: Rodriguez, A. et al.
**摘要**: 通过ChIP-seq结合PWP1抗体，揭示了PWP1与表观遗传调控因子的相互作用，提示其在干细胞分化中的潜在表观遗传调控功能。
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**建议**：如需真实文献，可通过PubMed或Google Scholar搜索关键词“PWP1 antibody”、“PWP1 function”等，并筛选近年研究以获取最新进展。
The PWP1 (Periodic Tryptophan Protein 1) antibody is a tool used to detect and study the PWP1 protein, a conserved WD40-repeat domain-containing protein implicated in ribosome biogenesis. PWP1. also known as WDR55. is part of the UTP-B (U3 small nucleolar ribonucleoprotein) complex, which plays a critical role in 18S rRNA processing and the assembly of the small ribosomal subunit. This protein is essential for cell proliferation, differentiation, and maintaining genomic stability. Dysregulation of PWP1 has been linked to ribosomopathies, developmental disorders, and cancer, highlighting its importance in cellular homeostasis.
Antibodies targeting PWP1 are primarily utilized in molecular and cellular biology research to investigate ribosome biosynthesis pathways, cell cycle regulation, and disease mechanisms. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to localize PWP1 within nucleolar compartments, assess its expression levels under various conditions, or identify interaction partners. Commercial PWP1 antibodies are typically validated for specificity across human, mouse, or rat models. Recent studies have also explored PWP1's role in cancer progression, such as its overexpression in certain tumors, making it a potential biomarker or therapeutic target. Proper controls, such as knockout cell lines, are recommended to confirm antibody specificity in experimental setups.
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