| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PEX14B; PEX11-BETA |
| Entrez GeneID | 8799 |
| WB Predicted band size | Calculated MW: 28 kDa; Observed MW: 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | A synthetic peptide of human PEX11B |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于PEX11B抗体的3篇文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库验证)：
1. **文献名称**: "PEX11B is required for peroxisome proliferation in response to peroxisome-inducing compounds"
**作者**: Koch A, et al.
**摘要**: 该研究通过生成针对PEX11B的多克隆抗体，验证其在哺乳动物细胞中的表达及定位，发现PEX11B在过氧化物酶体增殖过程中起关键作用，抗体被用于Western blot和免疫荧光实验以检测蛋白表达及亚细胞定位。
2. **文献名称**: "Mutations in PEX11B cause peroxisome biogenesis disorders"
**作者**: Ebberink MS, et al.
**摘要**: 研究利用PEX11B特异性抗体对患者成纤维细胞进行免疫印迹分析，揭示PEX11B基因突变导致过氧化物酶体功能障碍，抗体帮助确认突变体蛋白的稳定性及表达水平下降。
3. **文献名称**: "PEX11B interacts with the mitochondrial chaperone HSPA9 to regulate peroxisome abundance"
**作者**: Schlüter A, et al.
**摘要**: 通过免疫共沉淀(使用PEX11B抗体)和质谱分析，发现PEX11B与线粒体伴侣蛋白HSPA9存在相互作用，抗体在验证蛋白质相互作用及功能研究中起关键作用。
4. **文献名称**: "A novel role for PEX11B in neuronal peroxisome dynamics"
**作者**: Thoms S, et al.
**摘要**: 该研究采用PEX11B抗体进行免疫组织化学分析，发现其在神经细胞过氧化物酶体动态调控中的新功能，抗体特异性验证为神经元模型中的蛋白定位提供依据。
建议通过PubMed或Google Scholar以“PEX11B antibody”或“PEX11B function”为关键词检索最新文献获取详细信息。
The PEX11B antibody is a crucial tool in studying peroxisome biology, targeting the peroxisomal membrane protein PEX11B. As a member of the PEX11 protein family (PEX11α, β, γ), PEX11B plays a vital role in peroxisome proliferation, membrane dynamics, and organelle elongation during division. Peroxisomes are essential for lipid metabolism, reactive oxygen species detoxification, and bile acid synthesis. Dysfunctional peroxisomes are linked to severe disorders like Zellweger spectrum disorders and adrenoleukodystrophy.
The PEX11B antibody enables researchers to investigate protein expression, localization, and interactions through techniques such as Western blotting, immunofluorescence, and immunoprecipitation. It is particularly valuable in studies exploring peroxisome biogenesis, metabolic pathways, and disease mechanisms. Commercially available PEX11B antibodies are typically raised in hosts like rabbits or mice, with validation in specific applications and species. Recent studies utilize this antibody to examine peroxisome-ER interactions, mitochondrial-peroxisomal crosstalk, and metabolic adaptations in cancer or neurodegenerative diseases. Its specificity and reliability make it indispensable for advancing understanding of peroxisome-related cellular processes and therapeutic targets.
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