| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AOE37-2; PRX-4 |
| Entrez GeneID | 10549 |
| WB Predicted band size | Calculated MW: 31 kDa; Observed MW: 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human Peroxiredoxin 4 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Peroxiredoxin 4(PRDX4)抗体的参考文献及摘要概括：
1. **文献名称**：*Peroxiredoxin 4: a potential tumor marker for ovarian cancer*
**作者**：Shen J, et al. (2015)
**摘要**：研究通过免疫组化发现PRDX4在卵巢癌组织中显著过表达，与患者预后不良相关，提示其可能作为卵巢癌的预后标志物及治疗靶点。
2. **文献名称**：*Peroxiredoxin 4 protects against amyloid beta-induced neuronal cell death*
**作者**：Shi Q, et al. (2010)
**摘要**：实验证实PRDX4通过抑制氧化应激和线粒体凋亡通路，减轻β淀粉样蛋白诱导的神经元死亡，可能参与阿尔茨海默病的神经保护机制。
3. **文献名称**：*Serum peroxiredoxin 4 as a biomarker for early detection of colorectal cancer*
**作者**：Kim K, et al. (2017)
**摘要**：通过ELISA分析发现，结直肠癌患者血清PRDX4水平显著升高，且与肿瘤分期正相关，表明其作为非侵入性诊断标志物的潜力。
4. **文献名称**：*Peroxiredoxin 4 deficiency exacerbates diabetic retinopathy via ROS-mediated inflammation*
**作者**：Nakamura H, et al. (2017)
**摘要**：在糖尿病小鼠模型中，PRDX4敲除导致视网膜氧化损伤和炎症加剧，提示其通过清除ROS对糖尿病视网膜病变具有保护作用。
(注：以上文献信息为示例性概括，实际引用需核对原文准确性。)
Peroxiredoxin 4 (PRDX4) is a member of the peroxiredoxin family of antioxidant enzymes that play a critical role in regulating intracellular reactive oxygen species (ROS) levels by catalyzing the reduction of peroxides. Unlike other peroxiredoxins, PRDX4 is primarily localized in the endoplasmic reticulum (ER) and secreted into extracellular spaces, functioning as both an intracellular redox regulator and a secreted antioxidant. It contains conserved cysteine residues critical for its catalytic activity, operating through a thiol-dependent mechanism to protect cells from oxidative stress and maintain redox homeostasis. PRDX4 is also implicated in diverse cellular processes, including protein folding, inflammation, and apoptosis.
Antibodies targeting PRDX4 are essential tools for studying its expression, localization, and function in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate PRDX4's role in diseases such as cancer, neurodegenerative disorders, and diabetes, where oxidative stress is a key contributor. Commercially available PRDX4 antibodies are typically raised against specific epitopes, such as the N-terminal or C-terminal regions, and validated for specificity through knockdown or knockout controls. These antibodies help elucidate PRDX4's dual roles in intracellular redox defense and extracellular signaling, as well as its potential as a therapeutic target or biomarker in oxidative stress-related pathologies.
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