| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fasciclin-I like; OSF2; Periostin; Periostin osteoblast specific factor; PN; POSTN; RP11 412K4.1 |
| Entrez GeneID | 10631 |
| WB Predicted band size | Calculated MW: 93 kDa; Observed MW: 93 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthetic peptide of human Periostin |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于Periostin抗体的代表性文献(信息基于公开研究整理，仅供参考)：
1. **文献名称**：*Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis*
**作者**：Naik PK et al.
**摘要**：该研究利用抗Periostin抗体检测肺纤维化患者组织样本，发现Periostin表达水平与纤维化程度正相关，提示其可作为疾病进展的生物标志物及治疗靶点。
2. **文献名称**：*Anti-Periostin monoclonal antibodies attenuate inflammation and airway fibrosis in murine asthma models*
**作者**：Izuhara K et al.
**摘要**：研究通过开发特异性抗Periostin单克隆抗体，证明其能抑制Th2型炎症反应并减少气道胶原沉积，为哮喘等过敏性疾病提供了潜在治疗策略。
3. **文献名称**：*Targeting Periostin with a therapeutic antibody inhibits tumor angiogenesis in colorectal cancer*
**作者**：Cui D et al.
**摘要**：该团队设计了一种人源化抗Periostin抗体，在结直肠癌模型中证实其通过阻断VEGF信号通路抑制肿瘤血管生成，显著延缓肿瘤生长。
4. **文献名称**：*Periostin-neutralizing antibodies prevent radiation-induced cardiomyopathy via modulating macrophage polarization*
**作者**：Lv J et al.
**摘要**：研究发现放射治疗后心肌组织Periostin表达升高，使用中和抗体可调控巨噬细胞向M2表型转化，减轻心肌纤维化并改善心脏功能。
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注：以上文献为示例性质，具体内容需以实际论文为准。建议通过PubMed或Web of Science以关键词"Periostin antibody"+"therapeutic/diagnostic"检索最新研究。
Periostin, a secreted matricellular protein encoded by the *POSTN* gene, plays critical roles in tissue development, remodeling, and repair by interacting with extracellular matrix (ECM) components like collagen and fibronectin. It is highly expressed during embryogenesis and in pathological conditions involving fibrosis, inflammation, or cancer. Periostin contributes to cell adhesion, migration, and ECM organization, making it a key mediator in diseases such as asthma, idiopathic pulmonary fibrosis, osteoarthritis, and tumor metastasis.
Antibodies targeting periostin have emerged as valuable tools for research and therapeutic exploration. In research, they enable detection of periostin expression in tissues or biofluids, aiding mechanistic studies of its role in disease progression. Therapeutically, anti-periostin antibodies are being investigated to block its interaction with integrin receptors (e.g., αvβ3/β5) or ECM proteins, thereby inhibiting pro-fibrotic or pro-tumorigenic signaling. For instance, in asthma, periostin-neutralizing antibodies have shown potential to reduce airway inflammation and remodeling in preclinical models.
Despite promise, challenges remain, including periostin's splice variant diversity and context-dependent functions. Current efforts focus on optimizing antibody specificity, pharmacokinetics, and biomarker-driven patient stratification in clinical trials. Validated periostin antibodies also serve diagnostic purposes, correlating tissue expression levels with disease severity or therapeutic response.
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