| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LIM mineralization protein; LMP; Protein enigma |
| Entrez GeneID | 9260 |
| WB Predicted band size | Calculated MW: 50 kDa; Observed MW: 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human PDLIM7 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇涉及PDLIM7抗体的代表性文献摘要(文献名为虚构示例，仅作参考)：
1. **"PDLIM7 regulates cell adhesion and invasion via TGF-β signaling in breast cancer"**
- **作者**: Smith A, et al.
- **摘要**: 本研究使用PDLIM7特异性抗体进行免疫组化分析，发现PDLIM7在乳腺癌组织中高表达，并通过调控TGF-β信号通路促进肿瘤细胞侵袭和转移。
2. **"The role of PDLIM7 in cytoskeletal organization of cardiomyocytes"**
- **作者**: Zhang L, et al.
- **摘要**: 通过Western blot和免疫荧光技术(使用兔源PDLIM7抗体)，揭示了PDLIM7通过与α-actinin相互作用维持心肌细胞骨架稳定性，影响心脏收缩功能。
3. **"PDLIM7 as a biomarker for poor prognosis in colorectal cancer"**
- **作者**: Chen Y, et al.
- **摘要**: 利用PDLIM7抗体进行组织芯片分析，证实PDLIM7高表达与结直肠癌患者生存率降低相关，机制涉及Wnt/β-catenin通路异常激活。
如需具体文献，建议在PubMed或Google Scholar中以“PDLIM7 antibody”、“PDLIM7 function”为关键词检索，并筛选涉及抗体应用(如WB、IHC、IP等)的研究。
**Background of PDLIM7 Antibody**
The PDLIM7 antibody is a tool designed to detect and study the protein PDLIM7 (PDZ and LIM domain protein 7), also known as Enigma or LMP5. PDLIM7 belongs to the PDZ-LIM protein family, characterized by the presence of a PDZ domain at the N-terminus and one or more LIM domains at the C-terminus. These domains facilitate protein-protein interactions, enabling PDLIM7 to act as a scaffold or adaptor molecule in cellular signaling pathways.
PDLIM7 is involved in cytoskeletal organization, cell adhesion, and intracellular signaling, particularly in regulating actin dynamics and stress fiber formation. It interacts with cytoskeletal components (e.g., α-actinin) and transcription factors (e.g., NF-κB), suggesting roles in linking mechanical forces to gene expression. PDLIM7 is expressed in various tissues, including muscle, heart, and cancer cells, and has been implicated in diseases such as cardiomyopathies, muscular dystrophy, and cancer progression.
The PDLIM7 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression, localization, and functional mechanisms. Researchers employ it to explore PDLIM7's contributions to cell motility, tumor metastasis, and tissue remodeling, making it valuable for both basic research and potential therapeutic targeting.
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