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Rabbit Monoclonal PCPTP1 Antibody

  • 中文名： PCPTP1抗体
  • 别    名： PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7
货号: IPDX21814
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Rat
IF 咨询技术 Rat
IHC 咨询技术 Rat
ICC 技术咨询 Rat
FCM 咨询技术 Rat
Elisa 咨询技术 Rat

产品详情

AliasesPTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7
Entrez GeneID5801
WB Predicted band sizeCalculated MW: 74 kDa; Observed MW: 74 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityRat
ImmunogenA synthetic peptide of human PCPTP1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

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参考文献

以下是关于PCPTP1(Protein Tyrosine Phosphatase PCPTP1.或PTP1B)抗体的3篇模拟参考文献(非真实文献，供示例参考)：

1. **文献名称**：PCPTP1 regulates insulin signaling through dephosphorylation of the insulin receptor in hepatocytes

**作者**：Johnson M, et al.

**摘要**：该研究利用特异性PCPTP1抗体进行免疫沉淀和Western blot分析，发现PCPTP1通过直接结合并去磷酸化胰岛素受体(IR)，调控肝脏胰岛素敏感性，为2型糖尿病机制研究提供新靶点。

2. **文献名称**：Role of PCPTP1 in HER2-positive breast cancer metastasis

**作者**：Chen L, et al.

**摘要**：通过免疫组化实验(使用PCPTP1抗体)，作者发现PCPTP1在HER2阳性乳腺癌组织中高表达，并通过调控EGFR/ERK信号通路促进肿瘤侵袭，提示其作为预后标志物的潜力。

3. **文献名称**：PCPTP1 antibody-based inhibition suppresses tumor growth in colorectal cancer models

**作者**：Wang Y, et al.

**摘要**：研究开发了一种高亲和力PCPTP1单克隆抗体，体外实验证实其可阻断PCPTP1与STAT3的相互作用，抑制结直肠癌细胞增殖，为靶向治疗提供实验依据。

注：PCPTP1可能指代PTP1B(PTPN1基因编码)，但具体名称需根据研究背景确认。实际文献需通过PubMed/Google Scholar检索关键词“PCPTP1 antibody”或“PTP1B antibody”获取。

背景信息

The PCPTP1 antibody is a tool used to detect and study the Protein Tyrosine Phosphatase Mitochondrial 1 (PTPMT1), also known as Phosphatase of Regenerating Liver 3 (PRL-3) or PTPase PCPTP1. This ubiquitously expressed enzyme belongs to the protein tyrosine phosphatase (PTP) family and localizes primarily to mitochondria, where it regulates lipid metabolism, energy homeostasis, and apoptosis by dephosphorylating phosphatidylglycerophosphate (PGP) during cardiolipin biosynthesis. Dysregulation of PCPTP1 has been linked to metabolic disorders, cancer progression, and mitochondrial dysfunction. For example, its overexpression in tumors is associated with enhanced cell proliferation, invasion, and chemoresistance. Researchers employ PCPTP1 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions with signaling pathways such as PI3K/AKT and MAPK. These antibodies are critical for elucidating its role in diseases and validating its potential as a therapeutic target. Commercial PCPTP1 antibodies are typically raised in rabbits or mice against specific epitopes, with validation in knockout models ensuring specificity. Studies using these reagents have advanced understanding of mitochondrial phosphatase biology and its implications in metabolic syndrome and oncology.

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