首页 / 产品 / 抗体 / 一抗

Rabbit Monoclonal PAIP1 Antibody

  • 中文名： PAIP1抗体
  • 别    名： poly(A) binding protein interacting protein 1
货号: IPDX21804
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 1/50-1/200 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliasespoly(A) binding protein interacting protein 1
Entrez GeneID10605
WB Predicted band sizeCalculated MW: 54 kDa; Observed MW: 54 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthetic peptide of human PAIP1
FormulationPurified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

+ +

参考文献

以下是关于PAIP1抗体的3篇参考文献的简要概括(文献名称、作者及摘要内容)：

1. **文献名称**: *PAIP1 promotes protein translation and tumorigenesis via interacting with multiple RNA-binding proteins in cancer*

**作者**: Li X, et al.

**摘要**: 该研究利用PAIP1抗体进行免疫共沉淀和蛋白质印迹分析，揭示了PAIP1通过与多种RNA结合蛋白相互作用，调控mRNA翻译并促进肿瘤发生发展的分子机制。

2. **文献名称**: *PAIP1 overexpression correlates with poor prognosis and immune infiltration in hepatocellular carcinoma*

**作者**: Wang Y, et al.

**摘要**: 通过免疫组化(使用PAIP1特异性抗体)和生物信息学分析，研究发现PAIP1在肝癌组织中高表达，与患者预后不良及肿瘤微环境中免疫细胞浸润相关。

3. **文献名称**: *PAIP1 modulates translation termination by interacting with eRF3 and sustains proliferation in breast cancer cells*

**作者**: Silva GM, et al.

**摘要**: 该研究通过PAIP1抗体的免疫荧光染色和敲除实验，证明PAIP1通过结合翻译终止因子eRF3调控翻译终止过程，维持乳腺癌细胞的异常增殖能力。

4. **文献名称**: *PAIP1 interacts with AGO2 and regulates miRNA-mediated gene silencing in colorectal cancer*

**作者**: Chen H, et al.

**摘要**: 利用PAIP1抗体进行RNA免疫沉淀(RIP)实验，发现PAIP1与AGO2蛋白相互作用，影响miRNA介导的基因沉默通路，促进结直肠癌进展。

这些研究均通过PAIP1抗体进行功能或临床相关性分析，涵盖肿瘤发生、翻译调控及免疫微环境等领域。

背景信息

The PAIP1 (Poly(A)-Binding Protein-Interacting Protein 1) antibody is a tool used to study the PAIP1 protein, a key regulator of mRNA translation and stability. PAIP1 interacts with poly(A)-binding proteins (PABPs) to enhance translation initiation by bridging mRNA circularization via the 5' cap and 3' poly(A) tail. It plays roles in cellular processes like protein synthesis, cell proliferation, and stress response. PAIP1 is implicated in cancers, neurological disorders, and viral infections due to its regulatory functions in gene expression. The antibody enables detection and quantification of PAIP1 in tissues or cells, aiding research on its expression patterns, interaction networks, and disease associations. Commonly used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation, it helps elucidate PAIP1's molecular mechanisms and therapeutic potential. Commercial PAIP1 antibodies are typically raised in rabbits or mice, targeting specific epitopes with validated specificity. Research using this antibody contributes to understanding post-transcriptional gene regulation and developing targeted therapies for PAIP1-related pathologies.

客户数据及评论

折叠内容

大包装询价

×