WB | 1/500-1/1000 | Human,Mouse,Rat |
IF | 1/20 | Human,Mouse,Rat |
IHC | 咨询技术 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | TP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein |
Entrez GeneID | 7161 |
WB Predicted band size | Calculated MW: 70 kDa; Observed MW: 80,70 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | A synthetic peptide of human p73 |
Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3条关于p73抗体的参考文献及其摘要概括:
1. **文献名称**:*"Differential expression of TAp73 and ΔNp73 isoforms in human cancers: implications for prognosis"*
**作者**:Schmidte et al.
**摘要**:该研究通过特异性p73抗体(区分TAp73和ΔNp73亚型)分析多种肿瘤组织,发现ΔNp73高表达与患者预后不良相关,提示其在肿瘤进展中的关键作用。
2. **文献名称**:*"Monoclonal antibodies specific for p73: comparative analysis in normal and malignant tissues"*
**作者**:Moll et al.
**摘要**:开发并验证了针对p73蛋白不同表位的单克隆抗体,证实其在免疫组化(IHC)和Western blot中的高特异性,并发现p73在卵巢癌中异常高表达。
3. **文献名称**:*"p73 function is inhibited by tumor-derived p53 mutants in mammalian cells"*
**作者**:Kartasheva et al.
**摘要**:利用p73特异性抗体研究p73与p53突变体的相互作用,发现某些p53突变体能抑制p73的转录活性,揭示了肿瘤中p53-p73通路异常的机制。
4. **文献名称**:*"p63 and p73 expression in developing and adult nervous systems"*
**作者**:Urist et al.
**摘要**:通过特异性抗体标记,系统分析p73蛋白在小鼠神经系统发育中的时空表达模式,发现其在神经元分化中具有重要调控功能。
(注:以上文献信息为示例,实际引用需以真实文献为准。)
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